Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Longitudinal study on the impact of meaning-centered group psychotherapy on the quality of life of patients with advanced colorectal cancer

ABSTRACT: Interventions: test group:Meaning-Centered Group Coaching;Situation Investigation Team:Investigation Primary outcome(s): MDASI-GI;QLICP-CR;MILS;HADS Study Design: Sequential

DISEASE(S): Colorectal Cancer

PROVIDER: 36809 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Expanding the MicroRNA Targeting Code: A Novel Type of Site with Centered Pairing

2010-06-25 | GSE22068 | GEO

Expanding the MicroRNA Targeting Code: A Novel Type of Site with Centered Pairing

Project description:We present “centered sites,” a class of microRNA target sites that lacks both perfect seed pairing and 3'-compensatory pairing and instead has 11–12 contiguous Watson–Crick pairs to the center of the microRNA. In elevated Mg2+, centered sites impart mRNA cleavage, but in cells, centered sites repress protein output without consequential Agronaute-catalyzed cleavage. Our study also identified novel extensively paired sites that are cleavage substrates in cultured cells and human brain. This expanded repertoire of cleavage targets and the identification of the centered site type help explain why central regions of many microRNAs are evolutionarily conserved. To study centered sites and identify miRNA cleavage targets, mRNA degradomes were sequenced from human brain and HeLa cells, and smallRNAs were sequenced from human brain and zebrafish embryo at 24 hours post fertilization (hpf). Replicates were combined before the analysis. Fastq files are not available for GSM548638 and GSM548639.

2010-06-25 | E-GEOD-22068 | biostudies-arrayexpress

Longitudinal analysis of the group A Streptococcus transcriptome

Project description:Identification of the genetic events that contribute to host-pathogen interactions is important for understanding the natural history of infectious diseases and developing therapeutics. Transcriptome studies conducted on pathogens have been central to this goal in recent years. However, most of these investigations have focused on specific end points or disease phases, rather than analysis of the entire time course of infection. To gain a more complete understanding of how bacterial gene expression changes over time in a primate host, the transcriptome of group A Streptococcus (GAS) was analyzed during an 86-day infection protocol in 20 cynomolgus macaques with experimental pharyngitis. The study used 260 custom Affymetrix (Santa Clara, CA) chips, and data were confirmed by TaqMan analysis. Colonization, acute, and asymptomatic phases of disease were identified. Successful colonization and severe inflammation were significantly correlated with an early onset of superantigen gene expression. The differential expression of two-component regulators covR and spy0680 (M1_spy0874) was significantly associated with GAS colony-forming units, inflammation, and phases of disease. Prophage virulence gene expression and prophage induction occurred predominantly during high pathogen cell densities and acute inflammation. We discovered that temporal changes in the GAS transcriptome were integrally linked to the phase of clinical disease and host-defense response. Knowledge of the gene expression patterns characterizing each phase of pathogen-host interaction provides avenues for targeted investigation of proven and putative virulence factors and genes of unknown function and will assist vaccine research. Keywords: other

2005-06-17 | GSE2713 | GEO

The AIN-centered DCN of delayed-type eyeblink conditioned mice

Project description:The AIN-centered DCN of delayed-type eyeblink conditioned mice

| PRJNA93869 | ENA

A SIRT1-centered Circuitry Regulates Breast Cancer Stemness and Metastasis

Project description:A SIRT1-centered Circuitry Regulates Breast Cancer Stemness and Metastasis

| PRJNA445823 | ENA

Transcription profiling of mouse AIN-centered DCN of delayed-type eyeblink conditioned mice (GEO Super Series)

Project description:This SuperSeries comprises the following subset Series:; GSE3651: The AIN-centered DCN of delayed-type eyeblink conditioned mice: 3-d paired training and sham negative control groups; GSE3652: The AIN-centered DCN of delayed-type eyeblink conditioned mice: 7-d paired and 7-d unpaired training groups; Anterior interpositus nucleus (AIN) is a proposed site of memory formation of eyeblink conditioning. A large part of the underlying molecular events, however, remains unknown. To elucidate molecular mechanisms, we examined transcriptional changes in the AIN of mice trained with delayed-type eyeblink conditioning; The data are not directly comparable between GSE3651 and GSE3652, given the different experimental time periods and amounts of cRNA used for hybridizations. Experiment Overall Design: Refer to individual Series

2008-06-12 | E-GEOD-3713 | biostudies-arrayexpress

A compendium of promoter-centered long-range chromatin interactions in diverse human tissues and cell types

Project description:A large number of genetic variants associated with human diseases are found in non-coding DNA and may contribute to illness by affecting gene regulation, but mechanistic study of these variants has been hindered by a lack of information of their potential regulatory targets. In order to overcome this limitation, we generate maps of long-range chromatin interactions centered on 19,539 promoters in 27 human cell/tissue types, and use this information to infer putative target genes of candidate cis-regulatory sequences throughout the human genome. In additional to known enhancer-promoter interactions, we also confirm widespread promoter-promoter interactions and obtain evidence suggesting enhancer-like function for many promoter regions. These promoter-centered chromatin interaction maps corroborate target genes of genetic variants defined in previous genome-wide association studies, predict new target genes of many disease-associated genetic variants, and contribute novel insights into a broad spectrum of human traits and diseases.

2019-07-31 | GSE86189 | GEO

ImmunoAgeing Longitudinal

Project description:An investigation of the role of immunosenescence in the development of clonal haematopoiesis.

| EGAS00001003183 | EGA

Expanding the MicroRNA Targeting Code: A Novel Type of Site with Centered Pairing

Project description:Expanding the MicroRNA Targeting Code: A Novel Type of Site with Centered Pairing

| PRJNA128943 | ENA

JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML

Project description:JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML

| PRJNA395851 | ENA