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The effect of low-dose esketamine on early postoperative recovery quality in patients undergoing laparoscopic radical resection of colorectal cancer

ABSTRACT: Interventions: Experimental group:Esketamine;Control group:Normal saline Primary outcome(s): Quality of recovery 15-item scale score Study Design: Parallel

PROVIDER: 37115 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Effects of Esketamine on inflammatory mediators, postoperative depression-like mood and intestinal flora in patients undergoing radical operation for lung cancer

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Esketamine Enhances Post-Stroke Microglial Proliferation and Attenuates Neuroinflammation by Disrupting the Src-Pannexin1 Interaction

Project description:Previous research has suggested the potential of esketamine in alleviating post-stroke neuroinflammation, yet the underlying mechanism remained elusive. In our research, we have observed that esketamine increased the number of M2 anti-inflammatory phenotype microglia in the infarcted area after stroke, and this phenomenon is partly associated with the suppression of Panx1. Further research revealed that esketamine suppresses the phosphorylation of sarcoma kinase (Src) at the tyrosine 416 (Y416) site and inhibits the interaction between Src and Panx1, ultimately suppressing the function of Panx1. However, we found esketamine's inhibitory effect on post-stroke Panx1 activation is the underlying mechanism driving the increase in unactivated microglia, yet esketamine's influence on microglial polarization is mediated through a mechanism independent of Panx1.Our research suggests that esketamine, as a drug already used in clinical anesthesia, could potentially provide a solution during the periprocedural period to mitigate the damage caused by aseptic inflammation post-stroke.

2024-09-17 | GSE277009 | GEO

Effects of atomized Esketamine combined with dexmedetomidine on postoperative pharyngalgia and perioperative stress response in patients with colorectal cancer

Project description:Interventions: Blank control group:Preoperative atomization of 5ml normal saline;Esketamine group:Preoperative atomization inhalation of 0.5mg/kg Esketamine plus normal saline to prepare 5ml;Dexmedetomidine group:Atomized inhalation of 1 ug/kg dexmedetomidine plus physiological saline is 5 ml;Dexmedetomidine combined with esketamine group:Atomized inhalation of 0.25mg/kg esketamine +0.5ug/kg dexmedetomidine plus normal saline was configured as 5ml 30min before surgery Primary outcome(s): Incidence of postoperative sore throat Study Design: Parallel

| 88491 | ecrin-mdr-crc

Effect of Esketamine combined with transversus abdominis muscle block on postoperative pain in patients undergoing laparoscopic radical colorectal cancer surgery: a randomized controlled trial

Project description:Interventions: Group C:general anesthesia;Group T:General anesthesia and transversus abdominis muscle block;Group E:General anesthesia and Esketamine;Group TE:General anesthesia,transversus abdominis muscle block and Esketamine Primary outcome(s): Pain Visual Analogue Scale;Quality of postoperative recovery Study Design: Parallel

| 86801 | ecrin-mdr-crc

Effect of esketamine and sufentanil on postoperative gastrointestinal function recovery in patients undergoing laparoscopic radical resection of colorectal cancer

Project description:Interventions: The experimental group:esketamine;The control group:sufentanil Primary outcome(s): Time of first postoperative anal exhaust Study Design: Parallel

| 80915 | ecrin-mdr-crc

The effect of sub-anaesthetic dose of esketamine on postoperative fatigue of in patients after laparoscopic radical resection of colorectal cancer

Project description:Interventions: group K:a bolus injection of 0.1 mg/kg esketamine intravenously after anesthesia induction, followed by a continuous intravenous infusion of 0.1 mg/kg/h throughout the operation;group C:a bolus injection of 0.1 mg/kg normal saline intravenously after anesthesia induction, followed by a continuous intravenous infusion of 0.1 mg/kg/h throughout the operation Primary outcome(s): identity consequence fatigue scale Study Design: Parallel

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Effects of esketamine on postoperative acute pain and cognitive function in patients with gastric colorectal tumors: a randomized controlled study

Project description:Interventions: Experimental group:esketamine;Control group:sufentanil Primary outcome(s): Postoperative pain score;patient controlled intravenous analgesia (PCIA) press number;Postoperative recovery quality assessment scale of 15 items Study Design: Parallel

| 80327 | ecrin-mdr-crc

Effects of the Different Doses of Esketamine on Postoperative Quality of Recovery in Patients Undergoing Modified Radical Mastectomy: A Randomized, Double-Blind, Controlled Trial

Project description:Purpose This study aims to investigate the effects of the different doses of esketamine on postoperative quality of recovery in patients undergoing modified radical mastectomy. Methods Ninety-nine female patients were randomly allocated to three groups: the low-dose esketamine group (group E1) (0.5 mg/kg loading, 2 µg/kg/h infusion), the high-dose esketamine group (group E2) (0.5 mg/kg loading, 4 µg/kg/h infusion), the control group (group C) (received normal saline). The primary outcome was the quality of recovery-15 (QoR-15) scores on postoperative day 1 (POD1) and days 3 (POD3). The secondary outcomes were the sleep quality scores on POD1, bispectral index (BIS) value at 10, 30, and 60 min after operation, numeric rating scale (NRS) pain scores within 24 h after surgery, nausea, vomiting, drowsiness, nightmare, and intraoperative awareness. Results The total QoR-15 scores were higher in group E1 and group E2 than in group C on POD1 and POD3 (P<0.05). The sleep quality scores on POD1 and BIS value at 10, 30, and 60 min after operation were higher in group E1 and group E2 than in group C (P<0.05). The NRS pain scores at 2, 4 and 6 h after surgery in group E1 and at 2, 4, 6, 12 and 24 h after surgery in group E2 were lower than in group C (P<0.05). The NRS pain scores at 6, 12 and 24 h after surgery in group E2 were lower than in group E1 (P<0.05). The incidence of drowsiness was higher in group E1 and group E2 than in group C (P<0.05). Conclusion Esketamine infusion improved to some extent the quality of recovery on POD1 and POD3 in patients undergoing modified radical mastectomy, especially 4 µg/kg/h esketamine was better, but the BIS value and incidence of drowsiness were significantly increased.

| S-EPMC9766490 | biostudies-literature

Effect of Ultrasound-Guided erector spinae plane block on postoperative recovery quality of laparoscopic colorectal cancer: a prospective double-blind, randomized control trial

Project description:Interventions: erector spinae plane block group:Ultrasound-guided erector spinae block will be performed before operation;Standard analgesia group:Multimodal analgesia with local incision block after operation Primary outcome(s): 40-item quality of recovery questionnaire;Postoperative Vas (Visual Analogue Scale) scores at rest;postoperative Vas scores at motion Study Design: Parallel

| 47641 | ecrin-mdr-crc

Effect of Esketamine combined with lumboquadrat nerve block on postoperative anxiety, depression and cognitive function in senile patients undergoing radical resection of colorectal cancer

Project description:Interventions: LP group:ropivacaine;ES group:ropivacaine+esketamine Primary outcome(s): Mini-mental State Examination (MMSE) Score;Hospital Anxiety and Depression Scale (HADS) Score Study Design: Parallel

| 85068 | ecrin-mdr-crc

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