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Retrospective Clinical Study on Prognosis of Colorectal cancer Patients with General Anesthesia Combined with Epidural Anesthesia

ABSTRACT: Interventions: General anesthesia + epidural test group:None;General anesthesia Control group:None Primary outcome(s): Surgery-related complications during perioperative period;Anesthesia-related complications during the perioperative period Study Design: Case-Control study

DISEASE(S): Colorectal Cancer

PROVIDER: 39250 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Expression data from sevoflurane anesthesia treated rat

Project description:Long noncoding RNAs (lncRNAs) play important roles in brain function modulation and neurodegenerative diseases. However, whether lncRNA regulations are involved in the mechanisms of perioperative neurocognitive disorders (PNCD), especially in anesthesia related brain dysfunction, remains unknown. We explored the expression and regulation pattern profiles of lncRNAs in the hippocampus of aged rats after sevoflurane anesthesia with microarrays.

2020-12-29 | GSE139220 | GEO

The effect of local anaesthetics on blood pressure volatility IV lidocaine vs epidural anesthesia in patients undergoing colorectal surgery

Project description:Interventions: intravenous lidocaine infusion during general anesthesia for colon surgery,combined general and epidural anesthesia for colon surgery;Active Comparator Procedure/Surgery,Active Comparator Procedure/Surgery;IV lidocaine,epidural anesthesia Primary outcome(s): Haemodynamics stability intraoperative period incidence of hypotension Study Design: Randomized

| 2567506 | ecrin-mdr-crc

Transcriptome analysis of the hippocampus in late postnatal mice after repeated ketamine anesthesia

Project description:Numerous recent studies showed that early anesthesia during neurodevelopment may induce changes in specific behaviors. We further studied the effects of early anesthetic exposures regarding addiction behavior later in life. Postnatal day (PND) 16 C57BL/6 mice received ketamine anesthesia for 5 consecutive days. Addiction behavior was evaluated 1 week after anesthesia treatment. Neurological changes after repeated anesthesia were evaluated using high-performance liquid chromatography, RNA sequencing, electrophysiology studies. Repeated ketamine anesthesia during the critical neurodevelopment period increased the expression of genes involved with action potential, and induced excitatory/inhibitory (E/I) imbalance in hippocampal CA1 pyramidal neurons of male mice. Such neurological changes were associated with increases in drug-induced contextual addiction memory.

2022-07-14 | GSE175894 | GEO

General Anesthesia Combined With Epidural Anesthesia Mitigates the Surgical Stress-related Immunosuppression in Patients With Colorectal Cancer

Project description:The purpose of this study is to prove whether general anesthesia combined with epidural anesthesia could better maintain body balance of Th1/Th2 and Treg/Th17 compared with general anesthesia, so as to reduce the surgical stress-related immunosuppression, and to improve the prognosis.

| 2154377 | ecrin-mdr-crc

RNA-seq analysis of human cancer cell lines of cervical HeLa, osteosarcoma U2OS, hepatocellular HepG2 and colon SW480 after treatment with local anesthetic lidocaine

Project description:Growing evidence has revealed that anesthetic management influences the prognosis of cancer patients. The application of local anesthesia during the perioperative period improves their outcomes. However, its precise mechanism is still unresolved. To elucidate the effect of lidocaine on cancer cell growth, we performed RNA-seq using these cell lines.

2022-02-28 | E-MTAB-11320 | biostudies-arrayexpress

CircRNA-miRNA in anesthesia-induced permanent nerve injury during caesarean delivery

Project description:Permanent nerve damage caused by anesthesia is a rare but critical issue, and the mechanism of it remains unclear. Large-scale analysis of changes in noncoding RNA such as circRNA and microRNA in anesthesia-related nerve damage may provide insight into the mechanism of anesthesia-induced nerve injury.

2022-08-02 | GSE135297 | GEO

Effect of epidural block combined with general anesthesia on perioperative NETosis expression in patients with colorectal cancer

Project description:Interventions: A group:Sevoflurane - opioid general anesthesia group;B group:Propofol - epidural block general anesthesia group Primary outcome(s): NETosis;neutrophil /lymphocyte ratio Study Design: Parallel

| 82852 | ecrin-mdr-crc

Gene expression profiles in liver of Sprague-Dawley rat using two types of anesthesia.

Project description:To reveal influence of anesthesia in toxicogenomics study, gene expression analysis of liver of Sprague-Dawley rat after isoflurane anesthesia or CO2/O2 anesthesia was performed. The liver samples were excised from each rat after isoflurane anesthesia or CO2/O2 anesthesia. The gene expression profiles in liver were measureed by Agilent microarray.

2015-07-24 | GSE71277 | GEO

Astrocytes modulate a specific paraventricular thalamus-prefrontal cortex projection to enhance consciousness recovery from sevoflurane anesthesia in mice

Project description:Previous studies have proved that astrocytes may be a key neural substrate that regulates wakefulness and consciousness recovery from general anesthesia, while the exact molecular target in astrocytes is still unclear. Using virus injection and in vivo fiber photometry in mice, we found both activating astrocytes and knocking down astrocytic Kir4.1 in paraventricular thalamus (PVT) promotes the consciousness recovery from sevoflurane anesthesia. Single-cell RNA sequencing of PVT reveals two distinct cellular subtypes of glutamatergic neurons: PVTGRM and PVTChAT neurons. Patch-clamp recording results proved that Astrocytic Kir4.1-mediated modulation of sevoflurane on PVT mainly works on PVTChAT neurons. Moreover, we found that PVTChAT neurons project mainly to the mPFC. This specific paraventricular thalamus to prefrontal cortex projection is involved in recovery of consciousness from sevoflurane anesthesia indirectly through modulation of astrocytes. In summary, our findings support the novel conception that the volatile anesthetic sevoflurane can inhibit PVT astrocytic Kir 4.1 to maintain and/or increase neuronal firing of PVTChAT neurons, which mainly projects to mPFC and promotes consciousness recovery from anesthesia.

2024-07-20 | GSE240388 | GEO

Single-cell RNA sequencing of microglia under awake and anesthesia-state

Project description:To probe potential differences between awake and anesthesia microglia, we performed the single-cell RNA sequencing (scRNA-seq) . Microglia were isolated by FACS as CD11b high CD45 low cells from awake and anesthesia mouse brains.

2023-08-07 | GSE217202 | GEO

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