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A vascular typing study based on superior mesenteric artery and vein variations that can reflect the extent of right colon lymphatic drainage and evaluate the difficulty of surgery

ABSTRACT: Interventions: experimental group:SMA-guided lymph node dissection;control group:SMV-guided lymphatic dissection Primary outcome(s): Operation time;Amount of bleeding;Conversion rate of laparotomy;Number of lymph nodes obtained;First anal exhaust time;First time out of bed;Drainage flow of drainage tube;indwelling time of drainage tube;Incidence of postoperative short-term complications;Rate of re-hospitalization 30 days after surgery;Rate of mortality 30 days after surgery;Local recurrence rate;Median disease-free survival time;Median overall survival time Study Design: Case-Control study

DISEASE(S): Colorectal Cancer

PROVIDER: 40635 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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A multicenter, randomized controlled trial for hand assisted laparoscopic, laparoscopic and robot-assisted radical resection of colorectal cancer

Project description:Interventions: Group 1:hand-assisted laparoscopic radical resection of colorectal cancer;Group 2:laparoscopic-assisted radical resection of colorectal cancer;Group 3:robot-assisted radical resection of colorectal cancer Primary outcome(s): height;weight;Surgical incision length;operation time;Intraoperative blood loss;Number of lymph nodes detected after operation;First exhaust time after surgery;Postoperative hospital stay;Postoperative complication rate;Reoperation rate;Mortality within 30 days after surgery;Intraoperative cost;Local recurrence rate;Disease free survival;Overall survival rate;Postoperative adjuvant chemoradiotherapy rate;First time out of bed after surgery;Time of first postoperative feeding;Time of first urethral catheter extraction after operation;The first time pulling drainage tube after surgery;Tumor staging and typing;Tumor site;Preoperative tumor markers;ASA sizing Study Design: Parallel

| 2683257 | ecrin-mdr-crc

Hyperthermic Intraperitoneal Treatment of rmhTNF for CRCPM: Phase II Clinical Trial

Project description:The goal of this study is planing to adopt intra-abdominal perfusion therapy of rmhTNF during radical colorectal cancer surgery to determine whether intra-abdominal therapy has an impact on postoperative intestinal function recovery, anastomotic leakage, postoperative bleeding, postoperative adhesion intestinal obstruction and other complications. On this basis, the effect of rmhTNF on postoperative peritoneal implantation metastasis and long-term survival was further studied. The main question it aims to answer is: To evaluate the safety and efficacy of rmhTNF in the treatment of peritoneal metastases in colorectal cancer. Participants will receive 1. Radical surgery: Surgical methods can be developed or endoscopic (including robotic surgery). Radical resection of colorectal cancer (corresponding resection of colon and rectum plus regional lymph node dissection, regional lymph node dissection including parenteral, intermediate and mesangial root lymph nodes) follows the principle of mesangectomy and tumorless operation. 2. Abdominal heat perfusion was performed twice: the first time, 5 million IUrmhTNF, dissolved in 30-50ml normal saline, was intraperitoneal heat perfusion into the surgical focus after the operation; the second time, rhatitrexed 2.5mg/m2 was injected into the abdominal cavity through thermoperfusion or drainage tube; 3. Postoperative systemic chemotherapy regimen: postoperative adjuvant chemotherapy should be started 3-4 weeks after surgery, and appropriately extended for patients with poor physique, but no later than 8 weeks after surgery. The chemotherapy regimen was determined by the clinician according to pathological stage, molecular typing, and risk factors, referring to the NCCN and CSCO guidelines.

| 10462 | ecrin-mdr-crc

Gene array data of tumour draining lymph node fibroblastic reticular cells (FRCs)

Project description:Lymph node (LN) stromal cells, particularly fibroblastic reticular cells (FRCs), provide critical structural support and regulate immunity, tolerance and transport properties of LNs. In many tumors, LN metastasis is predictive of poor prognosis, however, stromal contribution to the evolving microenvironment of tumor draining LNs (TDLN) remains poorly understood. Here we present comparative transcriptional data of resting and TDLN FRCs after different time points of tumor drainage. FRCs were isolated from lymph nodes and FACS sorted based on the expression of CD45-, CD31- and PDPN+

2016-07-11 | GSE73728 | GEO

Transcriptome analysis of peripheral lymphoid tissue immediately before and after the detection of PrPSc in sheep scrapie 2

Project description:Sheep scrapie is a transmissible spongiform encephalopathy (TSE), which are invariably fatal neurodegenerative diseases of the central nervous system (CNS). Accumulation of the misfolded prion protein, PrPSc in the CNS results in progressive neurodegenerative disease. For many transmissible spongiform encephalopathies (TSEs), peripheral lymphoid tissue is an important site of PrPSc amplification but without obvious immunological consequence. Susceptible VRQ homozygous New Zealand Cheviot sheep were infected with SSBP/1 scrapie by inoculation in the drainage area of the prescapular lymph nodes. PrPSc was consistently detected by immunohistology in these nodes at 50 days post infection (dpi). This study compares the genes and physiological pathways that are affected by the progression of TSE disease in the prescapular lymph nodes, focussing on time points immediately before (10 dpi) and after (50 dpi) the detection of disease-associated PrPSc.

2014-04-06 | E-MTAB-2330 | biostudies-arrayexpress

Transcriptome analysis of peripheral lymphoid tissue immediately before and after the detection of PrPSc in sheep scrapie

Project description:Sheep scrapie is a transmissible spongiform encephalopathy (TSE), which are invariably fatal neurodegenerative diseases of the central nervous system (CNS). Accumulation of the misfolded prion protein, PrPSc in the CNS results in progressive neurodegenerative disease. For many transmissible spongiform encephalopathies (TSEs), peripheral lymphoid tissue is an important site of PrPSc amplification but without obvious immunological consequence. Susceptible VRQ homozygous New Zealand Cheviot sheep were infected with SSBP/1 scrapie by inoculation in the drainage area of the prescapular lymph nodes. PrPSc was consistently detected by immunohistology in these nodes at 50 days post infection (dpi). This study compares the genes and physiological pathways that are affected by the progression of TSE disease in the prescapular lymph nodes, focusing on time points immediately before (10 dpi) and after (50 dpi) the detection of disease-associated PrPSc.

2014-02-20 | E-MTAB-2327 | biostudies-arrayexpress

Differential gene expression in CNS after scrapie infection 2

Project description:Sheep scrapie is a transmissible spongiform encephalopathy (TSE), which are invariably fatal neurodegenerative diseases of the central nervous system (CNS). Accumulation of the misfolded prion protein, PrPSc in the CNS results in progressive neurodegenerative disease. Susceptible VRQ homozygous New Zealand Cheviot sheep were infected with SSBP/1 scrapie by inoculation in the drainage area of the prescapular lymph nodes. PrPSc was consistently detected by immunohistology in the CNS at 125 days post infection (dpi). This study compares the genes and physiological pathways that are affected by the progression of TSE disease in the CNS, focusing on time points immediately before (75dpi) and at the time point when PrPSc is consistently detected in the CNS (125 dpi).

2014-06-01 | E-MTAB-2385 | biostudies-arrayexpress

Lymph flow in colorectal cancers using real-time ICG imaging

Project description:Interventions: 1 injection of indocyanine green(2.5mg/ml) into submucosa of colon and rectum in colorectal cancer patients 2 Expansion of lymph nodes dissection area according to the acquired information by indocyanine green visualization Primary outcome(s): Positive rate of lymph node metastasis in the additional area of lymph node dissection Study Design: Single arm Non-randomized

| 2651801 | ecrin-mdr-crc

Differential gene expression in CNS after scrapie infection

Project description:Sheep scrapie is a transmissible spongiform encephalopathy (TSE), which are invariably fatalM- neurodegenerative diseases of the central nervous system (CNS). Accumulation of the misfolded prion protein, PrPSc in the CNS results in progressive neurodegenerative disease. Susceptible VRQ homozygous New Zealand Cheviot sheep were infected with standard scrapie sheep prion (SSBP/1) scrapie by inoculation in the drainage area of the prescapular lymph nodes. PrPSc was consistently detected by immunohistology in the CNS at XX days post infection (dpi). This study compares the genes and physiological pathways that are affected by the progression of TSE disease in the CNS, focusing on time points immediately before (XX dpi) and after (XX dpi) the detection of disease-associated PrPSc.

2014-06-01 | E-MTAB-2369 | biostudies-arrayexpress

Transformation of Human Fallopian Tube Stem Cells and high grade serous ovarian cancer

Project description:High-grade serous ovarian cancer (HGSOC) progresses to advanced stages without symptoms and the 5-year survival rate is a dismal 30%. Recent studies of ovaries and oviducts in patients with BRCA mutations revealed that premalignant HGSC is found almost exclusively in the fallopian tube. To validate this notion, we cloned and transformed the fallopian tube stem cells (FTSC). We demonstrated that the tumors derived from the transformed fallopian tube stem cells (FTSCt) share the similar histological and molecular feature of high-grade serous cancer. In addition, a whole-genome transcriptome analysis comparing between FTSC, immortalized fallopian tube stem cells (FTSCi), and FTSCt showing a clear molecular progression, which is mimicked by the gene expression comparison between laser captured normal oviducts and HGSOC ( cancer and paired normal samples from 10 patients).

2015-09-29 | GSE69428 | GEO

Clinical application of laparoendoscopic single-site surgery for colorectal cancer: a randomized controlled trial.

Project description:Interventions: A:laparoendoscopic single-site surgery for colorectal cancer;B:standard laparoscopic surgery for radical colorectal cancer Primary outcome(s): VAPS;fart time;Hospitalization time;Incision infection;abdominal drainage time;Surgical time;hemorrhage amount;Number of lymph nodes;surgical margins;Anastomotic fistula;CEA;CA199 Study Design: Parallel

| 2701750 | ecrin-mdr-crc

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