Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

To evaluate the efficacy and safety of endoscopic surgical system assisted laparoscopic colorectal cancer resection in clinical trials

ABSTRACT: Interventions: Experimental group:KangDuo endoscopic surgical system;Control group:da Vinci endoscopic surgical system Primary outcome(s): Successful operation Study Design: Parallel

DISEASE(S): Colorectal Cancer

PROVIDER: 42225 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Feasibility study of robot assisted colorectal cancer surgery using the da Vinci surgical system

Project description:Interventions: Laparoscopic rectal surgery using da Vinci surgical system Primary outcome(s): Adverse event rate Study Design: Single arm Non-randomized

| 2632792 | ecrin-mdr-crc

A pilot study of robot assisted colorectal cancer surgery using the da Vinci surgical system

Project description:Interventions: A group: We perform radical resection for colorectal cancer by using the da Vinci surgical system. We performe 3 months follow-up for the patients after the operation. Primary outcome(s): Adverse event rate Study Design: Single arm Non-randomized

| 2628778 | ecrin-mdr-crc

A pilot study of robot assisted colorectal cancer surgery using the da Vinci Si surgical system

Project description:Interventions: robot-assisted colorectal cancer surgery using the da Vinci Si Surgical System Primary outcome(s): The conversion rate to open surgery Study Design: Single arm Non-randomized

| 2649321 | ecrin-mdr-crc

Robot (Da Vinci) -assisted colorectal surgery

Project description:Interventions: Robot-assisted colorectal surgery using da Vinci Surgical System will be performed. Primary outcome(s): operation time, blood loss Study Design: Single arm Non-randomized

| 2632402 | ecrin-mdr-crc

A Feasibility Study of Robot-Assisted Laparoscopic Surgery for the Treatment of Colorectal Cancers

Project description:Interventions: Robot-assisted laparoscopic operation using "da Vinci Surgical System" will be performed. Primary outcome(s): Intraoperative and postoperative morbidity rate, Ro resection rate Study Design: Single arm Non-randomized

| 2628839 | ecrin-mdr-crc

da Vinci SP Investigational Device Exemption Study in Colorectal Procedures

Project description:To confirm the safety and performance of the da Vinci SP Surgical System, Instruments and Accessories in a complex colorectal procedure such as low anterior resections or right colectomy.

| 2340355 | ecrin-mdr-crc

Project description:Microbiome of drawings by Leonardo Da Vinci

| PRJNA655381 | ENA

A randomized clinical trial of Da Vinci robot VS laparoscopic radical resection for colorectal cancer

Project description:Interventions: Da Vinci robotic surgery group:Da Vinci robotic;Laparoscopic surgery group :Laparoscopic Primary outcome(s): Recent clinical outcome measures;Markers of inflammat Study Design: Randomized parallel controlled trial

| 2663935 | ecrin-mdr-crc

Fracture hematoma proteomics: surgical invasiveness characterizes the early fracture healing cascade after multiple trauma

Project description:Purpose The aim of this study was to determine the fracture hematoma (fxH) proteome after multiple trauma using label free proteomics, comparing two different established surgical treatment strategies. Basic procedures A large animal (sus scrofa), multiple trauma animal model was used in which two different trauma surgical treatment methods were compared: Early Total Care (ETC) versus Damage Control Orthopedics (DCO). fxH was harvested after 72 hours and analyzed using liquid chromatography-tandem mass spectrometry. Protein interaction analyses were performed to further elucidate key biomolecular pathways in the early fracture healing phase. Main findings The proteome of the early fxH was characterized by immunomodulatory and osteogenic proteins, as well as proteins involved in the coagulation cascade. Distinct, treatment-specific proteome alterations were observed. The fxH proteome of the ETC group showed increased expression of pro-inflammatory proteins related to, among others, activation of the complement system, neutrophil functioning, and macrophage activation, while showing decreased expression of proteins related to osteogenesis and tissue remodeling. On the other hand, the fxH proteome of the DCO group contained various upregulated or exclusively detected proteins related to tissue regeneration and remodeling, as well as proteins related to anti-inflammatory and osteogenic processes. Principal conclusions The early fxH proteome of the ETC group was characterized by the expression of immunomodulatory, mainly pro-inflammatory, proteins, whereas the early fxH proteome of the DCO group was more regenerative and osteogenic in nature. These findings match clinical observations, in which enhanced surgical trauma after severe multiple trauma causes dysbalanced inflammation, potentially leading to reduced tissue regenerative capabilities, and gained insights into regulatory mechanisms of fracture healing after severe trauma.

2024-05-24 | PXD049002 | Pride

Gene Expression Profiling of FFPE Pre-treatment Endoscopic Biopsies from Oesophageal Adenocarcinoma Patients Treated with Neo-adjuvant Chemotherapy and Surgical Resection

Project description:Gene expression profiling of 273 pre-treatment endoscopic FFPE oesophageal and oesophago-gastric junctional adenocarcinomas for validation of a DNA Damage Response Deficiency Assay. All patients were treated with neo-adjuvant chemotherapy followed by surgical resection and were collected at four UK centres in the Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) consortium between 2004 and 2013. Biopsies were reviewed for pathological subtype prior to marking for macrodissection and samples containing at least 50% adenocarcinoma tissue by area were taken forward. Total RNA was extracted using the RecoverallTM Total Nucleic Acid Isolation Kit for FFPE (Thermo Fisher Scientific, Waltham, MA) and amplified using the NuGen Ovation FFPE Amplification System v3 (NuGen San Carlos, CA). The amplified product was hybridized to the Almac Diagnostics Xcel™ array (Almac, Craigavon, United Kingdom), a cDNA microarray-based technology optimized for archival FFPE tissue, and analysed using the Affymetrix 7G scanner (Affymetrix, Santa Clara, CA)

2019-01-31 | E-MTAB-6969 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data