Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Assessment of the Diagnostic Role of Serum Insulin-like Growth Factor Binding Protein-3 as a Potential Biomarker for Colorectal Cancer (CRC) in Egypt

ABSTRACT: 1. evaluation of diagnostic importance of insulin like growth factor binding protein3 in patient with recently diagnosed as Colorectal cancer 2. correlation between the diagnostic efficacy of insulin like growth factor binding protein 3 with routine marker carcinoembryonic antigen.

DISEASE(S): Colorectal Cancer,Colorectal Neoplasms

PROVIDER: 59449 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Insulin-like Growth Factor Binding Protein-7 (IGFBP7) regulation in Hepatocellular Carcinoma

Project description:Insulin like growth factor binding protein-7 (IGFBP7) inhibits IGF signaling and functions as a potential tumor suppressor for hepatocellular carcinoma (HCC). We profiled genome-wide gene expression of Igfbp7 knockout (Igfbp7-/-) mouse to demonstrate the constitutive activation of IGF signaling and its relationship to the accelerated carcinogen-induced HCC.

2019-08-01 | GSE85427 | GEO

The effect of insulin-like growth factor 1 and insulin on neutrophil polarization

Project description:The effect of insulin-like growth factor 1 and insulin on neutrophil polarization

| PRJNA814614 | ENA

Gastrodin alleviates cardiac hypertrophy by inhibition of insulin-like growth factor type 2/insulin-like growth factor type 2 receptor

Project description:Gastrodin alleviates cardiac hypertrophy by inhibition of insulin-like growth factor type 2/insulin-like growth factor type 2 receptor

| PRJNA689477 | ENA

Insulin-like Growth Factor Binding Protein 7 identified in aged dental pulp by single-cell RNA sequencing

Project description:Insulin-like Growth Factor Binding Protein 7 identified in aged dental pulp by single-cell RNA sequencing

| PRJNA1147216 | ENA

Intrauterine Botulinum Toxin A administration promotes thin endometrium regeneration in a manner dependent on regulatory effect of insulin-like growth factor-binding protein 3 on osteopontin proteolytic cleavage in mice

Project description:Intrauterine administration of BoTA might be a potential therapeutic strategy to promote endometrial regeneration via elevation of insulin-like growth factor binding protein 3 mediated osteopontin proteolytic cleavage

2022-07-15 | GSE207379 | GEO

The effect of insulin-like growth factor 1 and insulin on neutrophil polarization

Project description:We analyzed bone marrow derived neutrophils after they were left untreated, or treatment with LPS/IFNgamma (pro-inflammatory), IL4 (anti-inflammatory), insulin-like growth factor 1 and insulin to detect transcriptional changes after the different treatments.

2022-03-13 | GSE198319 | GEO

Insulin-like growth factor 2 mRNA-binding protein 3 modulates aggressiveness of Ewing sarcoma by regulating the CD164-CXCR4 axis

Project description:Insulin-like growth factor 2 mRNA-binding protein 3 modulates aggressiveness of Ewing sarcoma by regulating the CD164-CXCR4 axis

| PRJNA633384 | ENA

Study Assessing Potential Predictive Tumor Markers in Metastatic Colorectal Cancer

Project description:To estimate the progression free survival for subjects treated with panitumumab in combination with a chemotherapy regimen of oxaliplatin, 5-Fluorouracil (5-FU) and leucovorin (FOLFOX) as first-line chemotherapy regimen for subjects with metastatic colorectal cancer with WT (wild type) KRAS according to the IGFRp (protein receptor insulin growth factor) and MMP-7 (Matrilysin) expression.

| 2101702 | ecrin-mdr-crc

Reduced circulating insulin enhances insulin sensitivity in old mice and extends lifespan

Project description:The causal relationships between insulin levels, insulin resistance, and longevity are not fully elucidated. Genetic down-regulation of insulin/insulin-like growth factor 1 (Igf1) signaling components can extend invertebrate and mammalian lifespan, but insulin resistance, a natural form of decreased insulin signaling, is associated with greater risk of age-related disease in mammals. We compared Ins2+/- mice to Ins2+/+ littermate controls, on a genetically stable Ins1-null background. Proteomic and transcriptomic analyses of livers from 25 week-old mice suggested potential for healthier aging and altered insulin sensitivity in Ins2+/- mice. Halving Ins2 lowered circulating insulin by 25-34% in aged female mice, without altering Igf1 or circulating Igf1. Remarkably, decreased insulin led to lower fasting glucose and improved insulin sensitivity in aged mice. Moreover, lowered insulin caused significant lifespan extension, observed across two diverse diets. Our study indicates that elevated insulin contributes to age-dependent insulin resistance, and that limiting basal insulin levels can extend lifespan.

2017-05-31 | GSE99440 | GEO