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A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors

ABSTRACT: The main purpose of Part A of the study is to evaluate safety, tolerability and tracer uptake after a single intravenous (IV) administration of [68Ga]Ga-DPI-4452; Part B: is to determine the recommended phase 2 dose (RP2D) [maximum tolerated dose (MTD) or lower dose] for [177Lu]Lu-DPI-4452 for each tumor type; Part C: is to evaluate the preliminary antitumor activity of [177Lu]Lu-DPI-4452 as monotherapy.

DISEASE(S): Colorectal Cancer (crc),Pancreatic Ductal Adenocarcinoma (pdac),Carcinoma, Renal Cell,Clear Cell Renal Cell Cancer (ccrcc)

PROVIDER: 6652 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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