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KN 046 Plus Regorafenib in MSS Metastatic Colorectal Cancer

ABSTRACT: The study is an interventional Phase II clinical trial aiming to optimize immunotherapy strategies for microsatellite-stable colorectal cancer. We will include three types of metastatic colorectal cancer patients: those without liver metastasis, or carrying BRAF V600E mutation, or unable to tolerate chemotherapy as their initial or second-line treatment. The participants will receive a combination treatment of regorafenib and KN046 which is a PD-L1/CTLA-4 bispecific antibody. Treatment efficacy and safety profile would be evaluated in this study.

DISEASE(S): Colorectal Cancer,Colorectal Neoplasms

PROVIDER: 69278 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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