Dataset Information

NET-ex Evaluation of MRI of the liver in the diagnostic accuracy of extrahepatic metastases

ABSTRACT: Interventions: Group 1: Cohort study: retrospective, non-randomized, monocentric, single-arm study. This study is a retrospective cohort analysis. We evaluate data from patients with neuroendocrine tumors who underwent liver MRI with liver-specific contrast agent and 68Ga-DOTATATE (-TOC, NOC) PET/CT at a maximum interval of 3 months at the Institute of Clinical Radiology/ Clinic and Polyclinic of Radiology and the Clinic of Nuclear Medicine of the University Hospital of Munich during the period 2010-2021. The MRI sequences will be evaluated in 3 different sessions and compared and analyzed with the gold standard, PET/CT. Primary outcome(s): Sensitivity, specificity, negative and positive predictive value of liver MRI (for different sequences) for extrahepatic metastases. Study Design: Allocation: ; Masking: ; Control: ; Assignment: ; Study design purpose: diagnostic

DISEASE(S): Secondary Malignant Neoplasm Of Other And Unspecified Respiratory Organs,Secondary Malignant Neoplasm Of Large Intestine And Rectum

PROVIDER: 72206 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Similar Datasets

Project description:Interventions: Cohort: 10 patients with histologically proven squamous cell carcinoma (SCC) of the anus, presenting to Austin Health for chemo-radiotherapy from June 2015. Observation: for up to 3 years post-radiotherapy. Interventions additional to standard procedures for purpose of study are administered by qualified health professionals and include: Pre-radiotherapy imaging: During standard MRI imaging session – non-standard diffusion weighted MRI (dwMRI) and dynamic contrast enhanced (DCE) MRI scans within Radiology facility. During standard CT simulation session – additional CT scan in prone position within Austin Radiation Oncology. Post-Radiotherapy - 3-4 weeks post completion of radiotherapy - non-standard timepoint for these scans MRI session – including dwMRI and DCE MRI scans within Radiology facility. PET session - PET imaging within Austin Nuclear & Molecular Imaging department. A number of imaging scans are required to map disease for targeting of radiotherapy (RT), including CT, PET and MRI. Each provides slightly different information about the position, shape and composition of the disease that is used by a Radiation Oncologist to define where to target the radiation and how much radiation to deliver. We aim to add an extra, non-standard MRI imaging sequence called a diffusion weighted (dwMRI) scan, to understand the characteristics of the disease and how its use may change the size or shape of the target area so as to ensure complete treatment coverage and improved outcomes from treatment. Additionally, the use of contrast with MRI, dynamic contrast enhanced MRI (DCEMRI) has been shown in other cancer sites to help better identify and show the disease and to show response to treatment, and we wish to verify this in anal Primary outcome(s): Identify the differences in radiotherapy target volume definition on standard (CT, T1/T2 MRI and PET) versus non-standard imaging modalities (dwMRI & DCE-MRI).[2 years post-radiotherapy] Study Design: Purpose: Treatment; Allocation: Non-randomised trial; Masking: Open (masking not used);Assignment: Single group

Dataset Information

NET-ex Evaluation of MRI of the liver in the diagnostic accuracy of extrahepatic metastases

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets