Dataset Information

Effects of exercise on strength of Colorectal Cancer patients undergoing Chemotherapy

ABSTRACT: Interventions: The measurements will be taken before and after 8 weeks of intervention in 20 participants who will be randomly divided in a counterbalanced manner into two groups: Training (TG) and Control (CG). A researcher will perform the data collection in a blinded manner. The intervention will be performed only in the training group, in order to analyze the effectiveness of muscle co-contraction training on levels of maximum torque, muscle thickness, fatigue conditions and quality of life, and the expression of miRNAs. This training will be supervised by a Physical Education Professional in a virtual way. The CG group, on the other hand, will not perform the co-contraction training and will maintain the physical activities they already performed previously.For the muscle co-contraction training, the Physical Education Professional will send a Google Meet link to the participants. Meetings will occur virtually twice a week for eight weeks. The interval defined between one training session and another will be a minimum of 72 hours and a maximum of 96 hours. In all the meetings to be held with the research participants, the Physical Education Professional responsible for supervising the training will make sure that the participants have the camera open for safety reasons and to make postural corrections if necessary. Once positioned, the participants will receive the verbal instruction Try to contract your biceps and triceps simultaneously as hard as you can without your forearm moving and Try to contract your quadriceps and hamstrings simultaneously as hard as you can without your leg moving for the elbow and knee co-contractions, respectively. Each volunteer will have the opportunity to perform two five-second co-contractions (on each of the two exercises) for familiarization;G11.427.410.698.277 Primary outcome(s): After intervention, we expect a significative increase in the maximum isometric torque (Nm) of knee and elbow extension and flexion, measured by an isokinetic dynamometer equipment (Biodex, System 4 Pro, New York, NY, USA) with an acquisition frequency of 100 Hz.

DISEASE(S): Malignant Neoplasm Of Colon, Unspecified,C180

PROVIDER: 75110 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Similar Datasets

Project description:Muscle mass and strength reduce during ageing with a steeper decline in women around the age of 50, which suggests that the menopausal transition is one of the mechanisms for age-induced neuromuscular deteriorations. At the moment, there is no clear explanation for the decline in muscle properties although both physical exercise and maintaining near premenopausal estrogen levels by hormonal replacement have been helpful in their preservation. However, the molecular consequences of both treatments in skeletal muscle are mostly unknown. The goal of this genome-wide study was to investigate the transcriptional networks through which power training (PT) comprising of jumping activities and estrogen containing hormone replacement therapy (HRT) may aid in the prevention of functional limitation ensued from insufficient muscle mass and physical performance after menopause. We used m. vastus lateralis samples obtained from postmenopausal women participating in a yearlong randomized double-blinded placebo-controlled trial with PT and HRT interventions. Muscle samples were available from eight PT, ten HRT and nine control women. Women in the PT group participated in a progressive PT program comprising mostly of jumping exercises for lower limbs with additional resistance exercises for the upper body. HRT intervention was double-blinded. All participants used either estradiol/noretisterone acetate preparation or placebo. Using statistical threshold p-value <0.05 and |fold change| >1.2 we identified 665 genes being differentially expressed among the studied 50-57-yr-old postmenopausal women. We used the hierarchical clustering method with extensive enrichment analysis in order to reveal enrichment of known GO or KEGG functional categories among co-regulated gene-clusters. In the enrichment analysis false discovery rate was set to be less than 15%. Transcription of “response to contraction”-, “insulin signaling”- and “adipocytokine signaling”-genes were upregulated by PT. Both PT and HRT were similarly effective on transcriptional regulation of glycolytic energy metabolism and calcium signaling. The HRT specifically affected “mitochondrion”-genes. In addition, we identified functional categories, such as “muscle development”, which were changed during the trial in all study groups. Our study revealed transcriptional changes in several functional categories in thigh muscle tissue of early postmenopausal women. The results emphasize that during the first years of the postmenopausal period, muscle properties are under transcriptional modulation, which both PT and HRT partially counteract leading to preservation of muscle mass and performance. More specifically, our findings indicate that PT and HRT may function through improving energy metabolism, improving the response to contraction, preserving functionality of mitochondria and reducing reorganization of muscle tissue. Therefore these treatments are recommended for preservation of adequate muscle mass and function. 54 samples, which formed 3 study groups with 2 timepoints, i.e., 8 power training subjects, 10 hormone replacement subjects and 9 controls. 6 control subjects had replicated samples resulting in a total of 60 hybridizations.

Dataset Information

Effects of exercise on strength of Colorectal Cancer patients undergoing Chemotherapy

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets