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A longitudinal study of identification and predication of self-compassion trajectories among elderly patients with colorectal cancer

ABSTRACT: Primary outcome(s): self-compassion Study Design: Cross-sectional

DISEASE(S): Colorectal Cancer

PROVIDER: 81578 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Inflammatory markers and frailty in home-dwelling elderly, a cross-sectional study

Project description:Low-grade, chronic inflammation during ageing (“inflammageing”) is suggested to be involved in the development of frailty in older age. However, studies on the association between frailty, using the frailty index definition, and inflammatory markers are limited. The aim of this study was to investigate the relationship between inflammatory markers and frailty index (FI) in older, home-dwelling adults. Home-dwelling men and women aged ≥ 70 years old, living in South-East Norway were recruited and included in a cross-sectional study. The FI used in the current study was developed according to Rockwood’s frailty index and included 38 variables, resulting in an FI score between 0 and 1 for each participant. Circulating inflammatory markers (IL-6, CRP, IGF-1, cystatin C, cathepsin S, and glycoprotein Acetyls) were analyzed from non-fasting blood samples using ELISA. Whole-genome PBMC transcriptomics was used to study the association between FI score and inflammation. The present study was a cross-sectional study that included home-dwelling men and women aged ≥ 70 years old, living in the Skedsmo area, South-East Norway. The study was conducted in 2014/2015 and has been described previously [Ottestad I, Ulven SM, Øyri LKL, Sandvei KS, Gjevestad GO, Bye A, et al. Reduced plasma concentration of branched-chain amino acids in sarcopenic older subjects: a cross-sectional study. Br J Nutr. 2018;120(4):445-53]. The participants were recruited by the National Register and received an invitation letter by mail. Briefly, a total of 2820 subjects were invited, and 437 subjects participated in the study. The participants met for a single study visit, and data was collected on dietary intake, body weight and composition, physical performance, medical history, cognitive function, risk of malnutrition, anthropometric measurements, blood pressure, heart rate, and quality of life. Non-fasting blood samples were also collected.

2023-09-01 | GSE236927 | GEO

RNA-seq of the killifish N.furzeri during normal aging (cross-sectional and longitudinal study) and treatment with rotenone

Project description:The study consists of three parts: 1) normal aging in liver and skin (cross-sectional); 2) treatment with rotenone in brain, liver and skin; 3) longitudinal study of 45 fish with different ages at their death measured at two different time points by fin clipping Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2015-12-03 | GSE66712 | GEO

Inflammatory markers and frailty in home-dwelling elderly, a cross-sectional study

Project description:Inflammatory markers and frailty in home-dwelling elderly, a cross-sectional study

| PRJNA993142 | ENA

HNSCC samples vs. normal tonsil samples: self-self hybridization design

Project description:transcription profiling of human head and neck squamous cell carcinoma (HNSCC) samples vs. normal tonsil samples using a self-self hybridization experimental design on two-color arrays. Used to identify differentially expressed genes in tumor/normal samples, and compare the result to that of the same samples using the reference design experimental setting. Keywords: tumor/normal comparison

2009-01-22 | GSE13397 | GEO

2-year Longitudinal Analyses of Peripheral Blood RNA in Huntington's Disease gene-positive and control subjects

Project description:Samples collected in the course of the TRACK HD study and used to analyse association between gene expression in blood and symptomatic progression of Huntington's disease Longitudinal analysis of UHDRS TMS versus gene expression in individual subjects followed by cross-sectional comparisons across phenotype groups at each timepoint

2020-09-23 | GSE135589 | GEO

Investigation of oral microbiome composition in elderly Chinese patients with hypertension: A cross-sectional study

Project description:Investigation of oral microbiome composition in elderly Chinese patients with hypertension: A cross-sectional study

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EarlyCause. Cross-sectional study of major depressive disorder

Project description:EarlyCause. Cross-sectional study of major depressive disorder

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Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation

Project description:Cross-sectional single cell RNA sequencing (scRNAseq) of hepatic cells enzymatically isolated from murine models of toxin- (CCl4) or diet-induced (Gubra Amlyn Nash or GAN) liver fibrosis to identify macrophage populations associated with fibrosis.

2023-03-27 | GSE228232 | GEO

Expression data for participants in iWITH study at screening visit

Project description:A cross sectional study using data collected at the time of liver biopsy, the final eligibility assessment for participation in iWITH (NCT01638559), an immunosuppression withdrawal trial. Microarrays were used to understand the gene expression profile differences among the three histological clusters (Cluster 1, Cluster 2 and Cluster 3)

2018-11-13 | GSE118587 | GEO

Somatically Acquired Structural Genetic Differences; a Longitudinal Study of Elderly Danish Twins

Project description:Structural genetic variants like copy number variants (CNVs) comprise a large part of human genetic variation and may be inherited as well as somatically acquired. Recent studies have reported the presence of somatically acquired structural variants in the human genome and it has been suggested that they may accumulate in elderly individuals. To further explore the presence and the age-related acquisition of somatic structural variants in the human genome, we investigated CNVs acquired over a period of 10 years in 86 elderly Danish twins as well as CNV discordances between co-twins of 18 monozygotic twin pairs. Furthermore, the presence of mosaic structural variants was explored.

2016-06-23 | GSE76390 | GEO

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