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Investigation on the effect of a Chinese herbal formula on intestinal flora and immune function based on spleen deficiency syndrome in patients with colorectal cancer after chemotherapy: Protocol for a randomized controlled trial

ABSTRACT: Interventions: Control group A:Chemotherapy + probiotics;Control group B:Chemotherapy + Chinese Medicine;Treatment group:Chemotherapy + probiotics + Chinese medicine;Negative control group:None Primary outcome(s): Intestinal microbiota detection;TCM symptom score and efficacy evaluation Study Design: Parallel

DISEASE(S): Colorectal Cancer

PROVIDER: 83529 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Herbal formula YYJD induces lung cancer cell apoptosis via activation of EGR1

Project description:In this study,we demonstrated the transcription factor EGR1 is activated by TCM YYJD and such activation mediated YYJD-induced apoptosis in lung cancer cells and provided a novel insight to understand the anti-tumor mechanism of Chinese herb YYJD.

2018-11-01 | E-MTAB-7236 | biostudies-arrayexpress

Herbal formula YYJD induces lung cancer cell apoptosis via activation of EGR1 (RNA-seq)

2018-11-01 | E-MTAB-7237 | biostudies-arrayexpress

Investigating the Mechanism of Chinese Medicine Formula AACO Against Chronic Heart Failure by Network Pharmacology Analysis and Experimental Validation

Project description:A traditional Chinese medicine (TCM) formula, containing Astragalus membranaceus (Fisch.) Bunge, Aconitum wilsonii Stapf ex Veitch, Curcuma longa L., and Radix ophiopogonis (AACO), has clinically proven therapeutic value for the treatment of chronic heart failure (CHF). In this study, we explored the potential pharmacological mechanism underlying the activity of the AACO formula against CHF.

2024-11-20 | GSE217747 | GEO

Effects of Jianpi Lushi Jiedu Formula on postoperative recurrence of colorectal adenoma with spleen deficiency and dampness syndrome and its mechanism based on IL-6/JAK/STAT3 signaling pathway

Project description:Interventions: test group:Oral Chinese medicine;control group:Not taking medicine Primary outcome(s): Recurrence rate of colorectal adenoma Study Design: Case-Control study

| 80024 | ecrin-mdr-crc

Clinical study on the treatment of stage III - IV colorectal cancer of spleen deficiency and essence deficiency type with anticancer essence formula

Project description:Interventions: blank control group:Blank intervention;Chinese medicine experimental group:Oral administration of Kangai Jingfang Primary outcome(s): quality of life Study Design: Parallel

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Diagnosis and Treatment Regimen Study of Traditional Chinese Medcine in Colorectal Caner - An Analysis of Syndrome and Prescription based on Curative Effect Evaluation

Project description:Interventions: TCM group:traditional Chinese medicine;control group:western medicine Primary outcome(s): PFS Study Design: Cohort study

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A network pharmacology study of Chinese Medicine QSYQ to reveal its underlying multi-compound, multi-target, multi-pathway mode of action

Project description:Chinese medicine is a complex system guided by traditional Chinese medicine (TCM) theories, which has proven to be especially effective in treating chronic and complex diseases. However, the underlying modes of action (MOA) are not always systematically investigated. Herein, a systematic study was designed to elucidate the multi-compound, multi-target and multi-pathway MOA of a Chinese medicine ,QSYQ, on myocardial infarction. Male Sprague Dawley rat model of myocardial infarction were administered QSYQ intragastrically for 7 days while the control group was not treated. The differentially expressed genes (DEGs) were identified from myocardial infarction rat model treated with QSYQ, followed by constructing a cardiovascular disease (CVD)-related multilevel compound-target-pathway network connecting main compounds to those DEGs supported by literature evidences and the pathways that are functionally enriched.

2014-01-17 | GSE54134 | GEO

Optimizing Personalized Therapy for Rheumatoid Arthritis Using a Novel Drug Combination of Bioactive Chemical Constituents Derived from a Classic Chinese Herbal Formula

Project description:Personalized therapy of rheumatoid arthritis (RA) based on traditional Chinese medicine cold and hot syndromes is selection of the best treatment for an individual patient. Wutou Decoction (WTD) is one of the classic Chinese herbal formulae which achieve favorable therapeutic response in treating RA-cold syndrome. Microarray analysis based on the adjuvant induced arthritis model combined with characteristics of RA and cold/hot syndromes was performed to screen RA-cold and RA-hot-syndrome-related genes, as well as WTD effect genes.

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Chinese Herbal Formula (GCNY)-Medicated Serum Alleviates Peroxidation Induced by H2O2 in Human Microglial Cells

Project description:Transitional Chinese herbal medicine has a long history of applications for anti-aging and longevity purposes, and in our patent formula Gancao Nurish-Yin (GCNY) decoction, all of the ingredients show antioxidant properties. However, in real clinical practice, extractions of herbs are rarely applied alone but are prescribed as integrated formula. In order to investigate whether GCNY possess anti-oxidation potential, we applied GCNY as a formula to treat rats in order to acquire medicated serum, which was then added on H2O2 (200 μM)-modeled human microglial cell line HMC-3 in comparison with its controls.

2022-09-06 | GSE210945 | GEO

Clinical effect of Jianpi Lishi Jiedu Decoction on postoperative patients with spleen deficiency and dampness toxin type colorectal adenoma

Project description:Interventions: The experimental group:Chinese medicine Jianpi Lishi Jiedu recipe, twice a day, 25ml each time, 1 hour after breakfast and dinner, course of 3 months;The control group:Follow up and observation Primary outcome(s): Main symptoms of Patiens;Curative effect of TCM Syndrome;Recurrence rate of colorectal adenoma;Safety indicators (such as routine hematuria feces, liver and kidney function, ECG);Beta-catenin Study Design: Parallel

| 2704459 | ecrin-mdr-crc

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