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Biomarker analysis of efficacy of PD-1 antibody combined with anti-vascular therapy for colorectal cancer

ABSTRACT: Interventions: Group of colonrectal cancer:None Primary outcome(s): neutrophil-lymphocyte ratio Study Design: Cross-sectional

DISEASE(S): Colonrectal Cancer

PROVIDER: 83904 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Construction of a comprehensive nutritional index and its association with postoperative complications and 6-month and one year mortality in elderly patients undergoing elective colorectal cancer surgery

Project description:Interventions: Case series:None Primary outcome(s): Body mass index;Lymphocyte count;Albumin;Proprotein;General weight ratio;Hemoglobin Study Design: Cross-sectional

| 80644 | ecrin-mdr-crc

Vascular Surgery Patients with Elevated Neutrophil Lymphocyte Ratios Have Downregulated Neutrophil Complement RNA Expression

Project description:Elevated NLR (neutrophil-lymphocyte ratio) in elective vascular surgery (EVS) patients is associated with increased mortality independent of perioperative surgical outcome. To understand why high NLR is associated with higher mortality, we investigated neutrophil and lymphocyte transcriptome expression in patients undergoing EVS.

2022-08-17 | GSE211190 | GEO

A cohort study of nutritional factors and colorectal cancer with sarcopenia

Project description:Interventions: Colorectal cancer with sarcopenia group:None;Colorectal cancer without sarcopenia group:None;Colorectal cancer combined with malnutrition group:None;Colorectal cancer without malnutrition group:None Primary outcome(s): Body mass index;Prognostic nutritional index;Neutrophil/lymphocyte ratio;Systemic immune inflammation index;Skeletal muscle mass index;Calf circumference;Tumor markers Study Design: Factorial

| 2762000 | ecrin-mdr-crc

Effect of epidural block combined with general anesthesia on perioperative NETosis expression in patients with colorectal cancer

Project description:Interventions: A group:Sevoflurane - opioid general anesthesia group;B group:Propofol - epidural block general anesthesia group Primary outcome(s): NETosis;neutrophil /lymphocyte ratio Study Design: Parallel

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Methylation cytometric pretreatment blood immune profiles with tumor mutation burden as prognostic indicators for survival outcomes in head and neck cancer patients on anti-PD-1 therapy

Project description:Tissue biomarkers for immune checkpoint inhibitor (ICI) response are limited by tumor sample heterogeneity and availability. This study identifies clinically actionable pretreatment blood biomarkers that are associated with ICI treatment response and survival in recurrent/metastatic head and neck squamous cell carcinoma. A prospective multi-center study enrolled 100 patients before standard-of-care immunotherapy. Blood immune profiles, measured by methylation cytometry, were assessed alongside tumor mutational burden (TMB) and PD-L1 combined proportion score (CPS). TMB and PD-L1 CPS were available for 56 and 91 patients, respectively. High neutrophils, monocytes, and neutrophil-to-lymphocyte ratio were associated with worse survival, while high CD4T cells, especially naïve CD4T cells, and lymphocyte-to-monocyte ratio were associated with better survival. Significant interactions between TMB and peripheral immune profiles for both progression-free and overall survival were found. Clinically relevant pretreatment peripheral immune biomarkers were identified, demonstrating the potential of DNA-based immune profiling to predict ICI response before treatment.

2024-11-15 | GSE277573 | GEO

Comparative study on clinical pathological characteristics, treatment, and prognosis of early-onset and late-onset colorectal cancer

Project description:Interventions: Colorectal group:None Primary outcome(s): prognosis Study Design: Cross-sectional

| 105451 | ecrin-mdr-crc

Retrospective study on the prognostic factors influencing the overall survival of patients with colorectal cancer liver metastasis

Project description:Interventions: Single group:None Primary outcome(s): Overall survival Study Design: Cross-sectional

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A cross-sectional survey of symptoms, family history and pathological features of colorectal cancer patients in different age groups

Project description:Interventions: Trail group:None Primary outcome(s): pathological characteristics;symptoms Study Design: Cross-sectional

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Vascular Surgery Patients with Elevated Neutrophil Lymphocyte Ratios Have Downregulated Neutrophil Complement RNA Expression

Project description:Vascular Surgery Patients with Elevated Neutrophil Lymphocyte Ratios Have Downregulated Neutrophil Complement RNA Expression

| PRJNA869449 | ENA

Human immature neutrophils as a functional biomarker of systemic vascular pathologies

Project description:We used an ex vivo system of murine ER-Hoxb8 neutrophils that phenotypically and morphologically recapitulate neutrophil maturation stages during five days of in vitro culture in the presence of G-CSF. To investigate the development of the ROS system in neutrophils during their development, we compared transcriptomes of D0, D1, D3 and D5 Hoxb8 neutrophils.

2020-09-15 | GSE147910 | GEO

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