Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

An empirical study of personalized music listening improving cognitive function in patients with colorectal cancer

ABSTRACT: Interventions: experimental group:usual care + music listening;control group:usual care Primary outcome(s): cognitive function Study Design: Parallel

DISEASE(S): Colorectal Cancer

PROVIDER: 84113 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Music compensates for altered gene expression in age-related cognitive disorders

Project description:Extensive literature has explored the beneficial effects of music in age-related cognitive disorders (ACD), but limited knowledge exists regarding its impact on gene expression. We analyzed transcriptomes of ACD patients and healthy controls, pre-post a music session (n=60), and main genes/pathways were compared to those dysregulated in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) as revealed by a multi-cohort study (n=1269 MCI/AD and controls). Music was associated with 2.3 times more whole-genome gene expression, particularly on neurodegeneration-related genes, in ACD than controls. Co-expressed gene-modules and pathways analysis demonstrated that music impacted autophagy, vesicle and endosome organization, biological processes commonly dysregulated in MCI/AD. Notably, the data indicated a strong negative correlation between musically-modified genes/pathways in ACD and those dysregulated in MCI/AD. These findings highlight the compensatory effect of music on genes/biological processes affected in MCI/AD, providing insights into the molecular mechanisms underlying the benefits of music on these disorders.

2023-10-26 | GSE239282 | GEO

Measures to improving cognitive and non cognitive functions while receiving chemotherapy for cancer of large intestine

Project description:Intervention1: Exercise and Vit D supplement: STUDY PARTICIPANTS WILL BE TAUGHT EXERCISE TO BE CARRIED OUT MINIMUM 2.5 HOURS/ WEEK FOR 12 MONTHS FROM THE TIME OF RECRUITMENT AND WILL BE GIVEN VIT D SUPPLEMENTS OF 60,000 I.U. PER WEEK TO BE CONSUMED ORALLY FOR THE 1ST 4 WEEKS FOLLOWED BY 60,000 I.U. EVERY ALTERNATE WEEK FOR 8 WEEKS THE EFFECT WILL BE MEASURED USING STANDARDISED INSTRUMENTS FOR COGNITIVE AND NON COGNITIVE FUNCTIONS Control Intervention1: Standard treatment: It will be prescribed by the treating medical oncologist Primary outcome(s): I. Primary objectives a) To assess the cognitive and non cognitive function of participants in experimental group before and after planned intervention c) To compare the cognitive function of participants in experimental and control group before and after planned intervention II. Secondary Objectives a) To assess the non- cognitive function and serum TNF alpha levels of participants in control and study group before and after planned intervention Timepoint: 0,3,6,9,and 12 months

| 2591022 | ecrin-mdr-crc

Developing Risk Prediction Model and Testing the Effect of Dual Task Walking on Improving Cognitive Function in Patients With Colorectal Cancer

Project description:The aims of this three-year study are to explore cognitive function under different stages of colorectal cancer (CRC) and its related factors; and understand its disturbance and coping process caused by cancer-induced cognitive impairment (CICI) from patient perspective; and further to test effect of dual-task walking on improving cognitive function in CRC patients.

| 2347093 | ecrin-mdr-crc

A Longitudinal Investigation of Cognitive Function in Colorectal Cancer Patients

Project description:This is a prospective, longitudinal, controlled study of cognitive function and fatigue in patients with apparently localized CRC treated with adjuvant or neoadjuvant chemotherapy. In addition to following each patient over time (i.e. acting as their own control), a separate control group will consist of patients with early stage CRC (Stage A or B) who have had surgical resection of their tumour, but who do not require adjuvant chemotherapy, or patients with stage C CRC who have declined chemotherapy. Also included is a smaller sub-study of patients with limited metastatic CRC who are treated with more toxic chemotherapy To compare changes in cognitive function, as compared to baseline assessment, of patients with CRC who do, or do not, receive 5FU-based chemotherapy. The primary measures of cognitive function are the High Sensitivity Cognitive Screen (HSCS) & Coghealth.

| 2114569 | ecrin-mdr-crc

Cognitive Function and Fatigue in Colorectal Cancer (CRC) Patients After Chemotherapy

Project description:This is a prospective, longitudinal cohort study to evaluate fatigue and cognitive function in patients with colorectal cancer (CRC) treated with chemotherapy, and in patients with the same malignancy, that do not receive chemotherapy. A self-report questionnaire for fatigue (the FACT-F), and validated tests of cognitive function, will be applied at predetermined times before, during and after chemotherapy, to determine the incidence, severity and duration of these symptoms. Comparisons will be made in changes in cognition for individuals, as well as between the chemotherapy and the control group. Mechanisms that might lead to fatigue and/or cognitive decline will be investigated.

| 2018622 | ecrin-mdr-crc

a7c6772c-6536-4be8-97bf-75d167bc9b84 - samples

Project description:Full blood mRNA sequencing of myotonic dystrophy type 1 patients after care as usual (CAU), cognitive behavioural therapy (CBT) and cognitive behavioural therapy (CBT) with graded exercise therapy (CBT+GET).

| EGAD00001010010 | EGA

Characteristic of the transcriptomics in the early subcortical vascular cognitive impairment [RNA-Seq]

Project description:Two cohorts with cerebrovascular disease are included in the present study, i.e., SCD group and VCI group. Participants in SVD group has the normal cognitive function and others in VCI group show the worse cognitive function. The whole-blood is collected from each participant, and RNA sequencing is conducted in whole-blood samples. Characteristic of circRNA, lncRNA, miRNA and mRNA are identified in the present blood samples.

2022-04-28 | GSE201482 | GEO

Characteristic of the transcriptomics in the early subcortical vascular cognitive impairment [miRNA-Seq]

2022-04-28 | GSE201481 | GEO

Myokine irisin is a critical regulator of cognitive function

Project description:Myokine irisin is a critical regulator of cognitive function

| PRJNA728743 | ENA

LOSS OF NEURONAL TET2 ENHANCES HIPPOCAMPAL-DEPENDENT COGNITIVE FUNCTION

Project description:LOSS OF NEURONAL TET2 ENHANCES HIPPOCAMPAL-DEPENDENT COGNITIVE FUNCTION

| PRJNA721436 | ENA