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Effect of intraoperative temperature management on postoperative myocardial injury in patients with colorectal tumors

ABSTRACT: Interventions: aggressively warmed group:Core body temperature was maintained at 37 to 37.5 ° C;actively warmed group:Core body temperature was maintained at 36 to 36.5 ° C;routine thermal management group:Core body temperature was maintained at least 35 ° C Primary outcome(s): troponin I;core body temperature Study Design: Parallel

DISEASE(S): Colorectal Tumor

PROVIDER: 84514 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Effect of temperature protection on postoperative immune function in elderly patients with colorectal cancer

Project description:Interventions: Body temperature Protection group (T group):Intraoperative routine temperature protection+Inflatable heating system;Control group (C Group):Intraoperative routine temperature protection Primary outcome(s): interleukin 17 (IL17);transforming growth factor-ß (TGF-ß);Interleukin- 6 (IL-6);Intraoperative core body temperature;Incidence of postoperative complications;Lymphocyte count Study Design: Parallel

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Comparison between decreasing body temperature and keeping normal temperature before starting heated chemotherapy into abdomen on developing decreased body temperature after heated chemotherapy

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Temperature dependent gene expression levels at 28°C and 37°C for Pseudomonas aeruginosa PAO1

Project description:To further understand the gene expression characteristics of Pseudomonas aeruginosa PAO1, we have applied whole genome microarray expression profiling as a discovery platform to specify the temperature dependent expression of PAO1 genome at soil and human body temperature. We selected 28°C as temperature representative of the soil niche and 37°C for human body. The results from the temperature dependent transcriptome analysis are consistent to our previous published data that the phzM, ptsP and lasI genes expression is upregulated at 37°C [11]. The comparison analysis of the M18 genome expressional profiles at 28°C and 37°C indicated a total of 596 genes expressed in a temperature dependent manner over two fold.

2012-03-01 | GSE36161 | GEO

Vibrio cholerae temperature shift microarray analysis

Project description:Temperature is a crucial environmental signal that govers the occurrence of Vibrio cholerae and cholera outbreaks. To understand how temperature impacts the transcriptome of V. cholerae we performed whole-genome level transcriptional profiling using custom microarrays on cells grown at human body temperature (37 C) then shifted to temperatures V. cholerae experience in the environment (15 C and 25 C).

2016-05-09 | GSE81158 | GEO

Temperature dependent gene expression levels at 28°C and 37°C for rhizophere Rhizosphere Originating Biocontrol Strain Pseudomonas aeruginosa M18

Project description:To further understand the gene expression characteristics of originating biocontrol strain Pseudomonas aeruginosa M18, we have applied whole genome microarray expression profiling as a discovery platform to to specify the temperature dependent expression of M18 genome at rhizosphere and human body temperature. We selected 28°C as temperature representative of the rhizosphere niches and 37°C for human body. The results from the temperature dependent transcriptome analysis are consistent to our previous published data that the phzM, ptsP and lasI genes expression is upregulated at 37°C. The comparison analysis of the M18 genome expressional profiles at 28°C and 37°C indicated a total of 605 gene expressed in a temperature dependent manner over about two fold at 28°C compared that at 37°C, covering 10.6% genes in M18 whole genome.

2012-01-01 | GSE26518 | GEO

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Project description:In Sparus aurata, seasonal temperature variations outside the normal thermal range, may trigger physiological responses leading to pathologies and death. In the present study two groups of wild sea bream were exposed for 21 days to two temperature regimes: 16 ± 0.3 °C (control group) and 6.8 ± 0.3 °C (cold-exposed group). Samples were collected during the acute phase (0, 6 and 24 hours after temperature drop) and upon chronic exposure (21 days).

2014-08-27 | GSE51442 | GEO

Global transcriptome analysis of Stenotrophomonas maltophilia in response to human body temperature

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Alternative splicing coupled mRNA decay shapes the temperature-dependent transcriptome

Project description:Mammalian body temperature oscillates with the time of the day and is altered in diverse pathological conditions. We recently identified a body temperature-sensitive thermometer-like kinase, which alters SR protein phosphorylation and thereby globally controls alternative splicing (AS). AS can generate unproductive variants which are recognized and degraded by diverse mRNA decay pathways – including nonsense-mediated decay (NMD). Here we show extensive coupling of body temperature-controlled AS to mRNA decay, leading to global control of temperature-dependent gene expression (GE). Temperature-controlled, decay-inducing splicing events are evolutionarily conserved and pervasively found within RNA-binding proteins, including most SR proteins. AS-coupled poison exon inclusion is essential for rhythmic GE of SR proteins and has a global role in establishing temperature-dependent rhythmic GE profiles, both, in mammals under circadian body temperature cycles and in plants in response to ambient temperature changes. Together, these data identify body temperature-driven AS coupled mRNA decay as an evolutionary ancient, core clock-independent mechanism to generate rhythmic GE.

2020-11-01 | GSE158882 | GEO

A conserved kinase-based body temperature sensor globally controls alternative splicing and gene expression

Project description:Homoeothermic organisms maintain their core body temperature in a narrow, tightly controlled range. Whether and how subtle circadian oscillations or disease-associated changes in core body temperature are sensed and integrated in gene expression programs remains elusive. Furthermore, a thermo-sensor capable of sensing the small temperature differentials leading to temperature-dependent sex determination (TSD) in poikilothermic reptiles has not been identified. Here we show that the activity of CDC-like kinases (CLKs) is highly responsive to physiological temperature changes, which is conferred by structural rearrangements within the kinase activation segment. Lower body temperature activates CLKs resulting in strongly increased phosphorylation of SR-proteins in vitro and in vivo. This globally controls temperature-dependent alternative splicing and gene expression, with wide implications in circadian, tissue-specific and disease-associated settings. This temperature sensor is conserved across evolution and adapted to growth temperatures of diverse poikilotherms. The dynamic temperature range of reptilian CLK homologs suggests a role in TSD.

2020-02-14 | GSE143872 | GEO

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2012-11-18 | GSE14573 | GEO

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