Clinical

Dataset Information

0

Envolimab Monotherapy or Envolimab + CAPEOX as Neoadjuvant Therapy for Locally Advanced Colorectal Cancer


ABSTRACT: There exists substantial evidence suggesting that patients diagnosed with MSI-H/dMMR colorectal cancer can derive benefits from immunotherapy in the management of advanced colorectal cancer. In cases of locally advanced colorectal cancer exhibiting microsatellite instability (dMMR/MSI-H), patients exhibit low responsiveness to neoadjuvant chemotherapy, resulting in minimal rates of complete tumor remission and downstaging. Nevertheless, initial exploratory studies, characterized by modest sample sizes, reveal a favorable therapeutic effect of neoadjuvant immunotherapy in this particular patient population. Envality monoclonal antibody, the first PD-L1 antibody developed and manufactured in China, possesses noteworthy practical and societal value in the context of exploratory clinical research on neoadjuvant immunotherapy for locally advanced MSI-H/dMMR colorectal cancer patients. The objective of this study is to evaluate the safety and efficacy of Envality monoclonal antibody (PD-L1) as neoadjuvant therapy for locally advanced MSI-H/dMMR colorectal cancer through a prospective, multi-cohort phase II clinical trial. Additionally, this study aims to investigate the effectiveness and safety of Envality monoclonal antibody in combination with CAPEOX as a neoadjuvant treatment regimen for locally advanced pMMR colorectal cancer.

DISEASE(S): Colon Cancer,Immunotherapy,Colorectal Neoplasms,Neoadjuvant Therapy

PROVIDER: 90202 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

Similar Datasets

| 2729957 | ecrin-mdr-crc
2015-05-11 | E-GEOD-68629 | biostudies-arrayexpress
| 114549 | ecrin-mdr-crc
| 71055 | ecrin-mdr-crc
| 2375994 | ecrin-mdr-crc
| 2332565 | ecrin-mdr-crc
2023-05-31 | GSE233517 | GEO
| 46532 | ecrin-mdr-crc
| 2332769 | ecrin-mdr-crc
| PRJNA976474 | ENA