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MDACC-endo

ABSTRACT: Data Access Committee EGAC00001000066

PROVIDER: EGAC00001000066 | EGA |

REPOSITORIES: EGA

ACCESS DATA

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Publications

Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.

Liang Han H Cheung Lydia W T LW Li Jie J Ju Zhenlin Z Yu Shuangxing S Stemke-Hale Katherine K Dogruluk Turgut T Lu Yiling Y Liu Xiuping X Gu Chao C Guo Wei W Scherer Steven E SE Carter Hannah H Westin Shannon N SN Dyer Mary D MD Verhaak Roeland G W RG Zhang Fan F Karchin Rachel R Liu Chang-Gong CG Lu Karen H KH Broaddus Russell R RR Scott Kenneth L KL Hennessy Bryan T BT Mills Gordon B GB

Genome research 20121001 11

Endometrial cancer is the most common gynecological malignancy, with more than 280,000 cases occurring annually worldwide. Although previous studies have identified important common somatic mutations in endometrial cancer, they have primarily focused on a small set of known cancer genes and have thus provided a limited view of the molecular basis underlying this disease. Here we have developed an integrated systems-biology approach to identifying novel cancer genes contributing to endometrial tu ...[more]

PMID: 23028188

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