Dataset Information
HPV Virome Consortium Data Access Committee
Ontology highlight
ABSTRACT:
PROVIDER: EGAC00001000141 | EGA |
REPOSITORIES: EGA
Publications
Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.
Genome research 20131107 2
Genomic instability is a hallmark of human cancers, including the 5% caused by human papillomavirus (HPV). Here we report a striking association between HPV integration and adjacent host genomic structural variation in human cancer cell lines and primary tumors. Whole-genome sequencing revealed HPV integrants flanking and bridging extensive host genomic amplifications and rearrangements, including deletions, inversions, and chromosomal translocations. We present a model of "looping" by which HPV ...[more]