Dataset Information

Department of Pediatrics, The University of Tokyo Data Access Committee

ABSTRACT: Data Access Committee EGAC00001000207

PROVIDER: EGAC00001000207 | EGA |

REPOSITORIES: EGA

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Publications

Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma.

Seki Masafumi M Nishimura Riki R Yoshida Kenichi K Shimamura Teppei T Shiraishi Yuichi Y Sato Yusuke Y Kato Motohiro M Chiba Kenichi K Tanaka Hiroko H Hoshino Noriko N Nagae Genta G Shiozawa Yusuke Y Okuno Yusuke Y Hosoi Hajime H Tanaka Yukichi Y Okita Hajime H Miyachi Mitsuru M Souzaki Ryota R Taguchi Tomoaki T Koh Katsuyoshi K Hanada Ryoji R Kato Keisuke K Nomura Yuko Y Akiyama Masaharu M Oka Akira A Igarashi Takashi T Miyano Satoru S Aburatani Hiroyuki H Hayashi Yasuhide Y Ogawa Seishi S Takita Junko J

Nature communications 20150703

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood. Here we studied 60 RMSs using whole-exome/-transcriptome sequencing, copy number (CN) and DNA methylome analyses to unravel the genetic/epigenetic basis of RMS. On the basis of methylation patterns, RMS is clustered into four distinct subtypes, which exhibits remarkable correlation with mutation/CN profiles, histological phenotypes and clinical behaviours. A1 and A2 subtypes, especially A1, largely correspond to alveolar ...[more]

PMID: 26138366

Dataset Information

Department of Pediatrics, The University of Tokyo Data Access Committee

Publications

Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma.

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