Genomics

Dataset Information

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Department of Pediatrics, The University of Tokyo Data Access Committee

ABSTRACT: Data Access Committee EGAC00001000207

PROVIDER: EGAC00001000207 | EGA |

REPOSITORIES: EGA

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Publications

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood. Here we studied 60 RMSs using whole-exome/-transcriptome sequencing, copy number (CN) and DNA methylome analyses to unravel the genetic/epigenetic basis of RMS. On the basis of methylation patterns, RMS is clustered into four distinct subtypes, which exhibits remarkable correlation with mutation/CN profiles, histological phenotypes and clinical behaviours. A1 and A2 subtypes, especially A1, largely correspond to alveolar  ...[more]

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