Evolution of the African pygmy phenotype
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ABSTRACT:
PROVIDER: EGAC00001000216 | EGA |
REPOSITORIES: EGA
Publications
The epigenomic landscape of African rainforest hunter-gatherers and farmers.
Fagny Maud M Patin Etienne E MacIsaac Julia L JL Rotival Maxime M Flutre Timothée T Jones Meaghan J MJ Siddle Katherine J KJ Quach Hélène H Harmant Christine C McEwen Lisa M LM Froment Alain A Heyer Evelyne E Gessain Antoine A Betsem Edouard E Mouguiama-Daouda Patrick P Hombert Jean-Marie JM Perry George H GH Barreiro Luis B LB Kobor Michael S MS Quintana-Murci Lluis L
Nature communications 20151130
The genetic history of African populations is increasingly well documented, yet their patterns of epigenomic variation remain uncharacterized. Moreover, the relative impacts of DNA sequence variation and temporal changes in lifestyle and habitat on the human epigenome remain unknown. Here we generate genome-wide genotype and DNA methylation profiles for 362 rainforest hunter-gatherers and sedentary farmers. We find that the current habitat and historical lifestyle of a population have similarly ...[more]
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