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MPNST

ABSTRACT: Data Access Committee EGAC00001000253

PROVIDER: EGAC00001000253 | EGA |

REPOSITORIES: EGA

ACCESS DATA

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Publications

Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors.

Zhang Ming M Wang Yuxuan Y Jones Sian S Sausen Mark M McMahon Kevin K Sharma Rajni R Wang Qing Q Belzberg Allan J AJ Chaichana Kaisorn K Gallia Gary L GL Gokaslan Ziya L ZL Riggins Greg J GJ Wolinksy Jean-Paul JP Wood Laura D LD Montgomery Elizabeth A EA Hruban Ralph H RH Kinzler Kenneth W KW Papadopoulos Nickolas N Vogelstein Bert B Bettegowda Chetan C

Nature genetics 20141012 11

Neurofibromatosis 1 is a hereditary syndrome characterized by the development of numerous benign neurofibromas, a small subset of which progress to malignant peripheral nerve sheath tumors (MPNSTs). To better understand the genetic basis for MPNSTs, we performed genome-wide or targeted sequencing on 50 cases. Sixteen MPNSTs but none of the neurofibromas tested were found to have somatic mutations in SUZ12, implicating it as having a central role in malignant transformation. ...[more]

PMID: 25305755

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