Dataset Information
KUL-MEL
Laboratory of Molecular Endocrinology, KU Leuven
Ontology highlight
ABSTRACT:
PROVIDER: EGAC00001000260 | EGA |
REPOSITORIES: EGA
Publications
Genomic and epigenomic analysis of high-risk prostate cancer reveals changes in hydroxymethylation and TET1.
Oncotarget 20160401 17
The clinical heterogeneity of prostate cancer (PCa) makes it difficult to identify those patients that could benefit from more aggressive treatments. As a contribution to a better understanding of the genomic changes in the primary tumor that are associated with the development of high-risk disease, we performed exome sequencing and copy number determination of a clinically homogeneous cohort of 47 high-risk PCas. We confirmed recurrent mutations in SPOP, PTEN and TP53 among the 850 point mutati ...[more]