Dataset Information
Data Access Committee of DKFZ-Epigenomics
Ontology highlight
ABSTRACT:
PROVIDER: EGAC00001000279 | EGA |
REPOSITORIES: EGA
Publications
Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia.
Cancer discovery 20131219 3
Although clonal selection by genetic driver aberrations in cancer is well documented, the ability of epigenetic alterations to promote tumor evolution is undefined. We used 450k arrays and next-generation sequencing to evaluate intratumor heterogeneity and evolution of DNA methylation and genetic aberrations in chronic lymphocytic leukemia (CLL). CLL cases exhibit vast interpatient differences in intratumor methylation heterogeneity, with genetically clonal cases maintaining low methylation hete ...[more]
