Genomics

Dataset Information

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Data Access Committee of DKFZ-Epigenomics

ABSTRACT: Data Access Committee EGAC00001000279

PROVIDER: EGAC00001000279 | EGA |

REPOSITORIES: EGA

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Publications

Although clonal selection by genetic driver aberrations in cancer is well documented, the ability of epigenetic alterations to promote tumor evolution is undefined. We used 450k arrays and next-generation sequencing to evaluate intratumor heterogeneity and evolution of DNA methylation and genetic aberrations in chronic lymphocytic leukemia (CLL). CLL cases exhibit vast interpatient differences in intratumor methylation heterogeneity, with genetically clonal cases maintaining low methylation hete  ...[more]

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