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MGH Thoracic Oncology

ABSTRACT: Data Access Committee EGAC00001000284

PROVIDER: EGAC00001000284 | EGA |

REPOSITORIES: EGA

ACCESS DATA

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Publications

RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer.

Niederst Matthew J MJ Sequist Lecia V LV Poirier John T JT Mermel Craig H CH Lockerman Elizabeth L EL Garcia Angel R AR Katayama Ryohei R Costa Carlotta C Ross Kenneth N KN Moran Teresa T Howe Emily E Fulton Linnea E LE Mulvey Hillary E HE Bernardo Lindsay A LA Mohamoud Farhiya F Miyoshi Norikatsu N VanderLaan Paul A PA Costa Daniel B DB Jänne Pasi A PA Borger Darrell R DR Ramaswamy Sridhar S Shioda Toshi T Iafrate Anthony J AJ Getz Gad G Rudin Charles M CM Mino-Kenudson Mari M Engelman Jeffrey A JA

Nature communications 20150311

Tyrosine kinase inhibitors are effective treatments for non-small-cell lung cancers (NSCLCs) with epidermal growth factor receptor (EGFR) mutations. However, relapse typically occurs after an average of 1 year of continuous treatment. A fundamental histological transformation from NSCLC to small-cell lung cancer (SCLC) is observed in a subset of the resistant cancers, but the molecular changes associated with this transformation remain unknown. Analysis of tumour samples and cell lines derived f ...[more]

PMID: 25758528

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