Genomics

Dataset Information

0

Institut Curie Neuroblastoma data access Committee

ABSTRACT: Data Access Committee EGAC00001000319

PROVIDER: EGAC00001000319 | EGA |

REPOSITORIES: EGA

Json Xml
altmetric image

Publications

Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations.

Eleveld Thomas F TF   Oldridge Derek A DA   Bernard Virginie V   Koster Jan J   Colmet Daage Léo L   Diskin Sharon J SJ   Schild Linda L   Bentahar Nadia Bessoltane NB   Bellini Angela A   Chicard Mathieu M   Lapouble Eve E   Combaret Valérie V   Legoix-Né Patricia P   Michon Jean J   Pugh Trevor J TJ   Hart Lori S LS   Rader JulieAnn J   Attiyeh Edward F EF   Wei Jun S JS   Zhang Shile S   Naranjo Arlene A   Gastier-Foster Julie M JM   Hogarty Michael D MD   Asgharzadeh Shahab S   Smith Malcolm A MA   Guidry Auvil Jaime M JM   Watkins Thomas B K TB   Zwijnenburg Danny A DA   Ebus Marli E ME   van Sluis Peter P   Hakkert Anne A   van Wezel Esther E   van der Schoot C Ellen CE   Westerhout Ellen M EM   Schulte Johannes H JH   Tytgat Godelieve A GA   Dolman M Emmy M ME   Janoueix-Lerosey Isabelle I   Gerhard Daniela S DS   Caron Huib N HN   Delattre Olivier O   Khan Javed J   Versteeg Rogier R   Schleiermacher Gudrun G   Molenaar Jan J JJ   Maris John M JM  

Nature genetics 20150629 8

The majority of patients with neuroblastoma have tumors that initially respond to chemotherapy, but a large proportion will experience therapy-resistant relapses. The molecular basis of this aggressive phenotype is unknown. Whole-genome sequencing of 23 paired diagnostic and relapse neuroblastomas showed clonal evolution from the diagnostic tumor, with a median of 29 somatic mutations unique to the relapse sample. Eighteen of the 23 relapse tumors (78%) showed mutations predicted to activate the  ...[more]

Similar Datasets

Genomics Retinoblastoma Data Access Committee - Institut Curie
| EGAC00001002089 | EGA
Genomics Retinoblastoma Data Access Committee - Institut Curie
| EGAC00001002050 | EGA
Genomics Data Access Committee for Institut Curie
| EGAC00001002711 | EGA
Genomics Retinoblastoma Data Access Committee - Institut Curie
| EGAC00001002275 | EGA
Genomics Data Access Committee for Institut Curie
| EGAC00001000670 | EGA
Genomics Data Access Committee for Institut Curie Data
| EGAC00001000623 | EGA
Genomics Institut Curie Data Access Commitee
| EGAC00001003266 | EGA
Genomics Data access comittee for Institut Curie
| EGAC00001001042 | EGA
Genomics Neuroblastoma Data Access Committee
| EGAC00001000085 | EGA
Genomics SEER Remote Access Pilot Test Data (2018)
| PRJNA625583 | ENA