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Associations between APOE and cognitive ability in Generation Scotland.

ABSTRACT: Data Access Committee EGAC00001000332

PROVIDER: EGAC00001000332 | EGA |

REPOSITORIES: EGA

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Differential effects of the APOE e4 allele on different domains of cognitive ability across the life-course.

Marioni Riccardo E RE Campbell Archie A Scotland Generation G Hayward Caroline C Porteous David J DJ Deary Ian J IJ

European journal of human genetics : EJHG 20150923 6

The association between APOE genotype and cognitive function suggests a positive role for the e2 allele and a negative role for the e4 allele. Both alleles have relatively low frequencies in the general population; hence, meta-analyses have been based on many small, heterogeneous studies. Here, we report the APOE-cognition associations in the largest single analysis to date. APOE status and cognitive ability were measured in 18 337 participants from the Generation Scotland study between 2006 and ...[more]

PMID: 26395552

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