Dataset Information
Oxford Human Islet Data Access Committee
Ontology highlight
ABSTRACT:
PROVIDER: EGAC00001000335 | EGA |
REPOSITORIES: EGA
Publications
Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.
PLoS genetics 20151201 12
The intersection of genome-wide association analyses with physiological and functional data indicates that variants regulating islet gene transcription influence type 2 diabetes (T2D) predisposition and glucose homeostasis. However, the specific genes through which these regulatory variants act remain poorly characterized. We generated expression quantitative trait locus (eQTL) data in 118 human islet samples using RNA-sequencing and high-density genotyping. We identified fourteen loci at which ...[more]
