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TRACERx esophageal adenocarcinoma

ABSTRACT: Data Access Committee EGAC00001000340

PROVIDER: EGAC00001000340 | EGA |

REPOSITORIES: EGA

ACCESS DATA

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Publications

Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy.

Murugaesu Nirupa N Wilson Gareth A GA Birkbak Nicolai J NJ Watkins Thomas T McGranahan Nicholas N Kumar Sacheen S Abbassi-Ghadi Nima N Salm Max M Mitter Richard R Horswell Stuart S Rowan Andrew A Phillimore Benjamin B Biggs Jennifer J Begum Sharmin S Matthews Nik N Hochhauser Daniel D Hanna George B GB Swanton Charles C

Cancer discovery 20150523 8

<h4>Unlabelled</h4>Esophageal adenocarcinomas are associated with a dismal prognosis. Deciphering the evolutionary history of this disease may shed light on therapeutically tractable targets and reveal dynamic mutational processes during the disease course and following neoadjuvant chemotherapy (NAC). We exome sequenced 40 tumor regions from 8 patients with operable esophageal adenocarcinomas, before and after platinum-containing NAC. This revealed the evolutionary genomic landscape of esophagea ...[more]

PMID: 26003801

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