Dataset Information
Pancreatic Adenocarcinoma Data Access Committee
Ontology highlight
ABSTRACT:
PROVIDER: EGAC00001000358 | EGA |
REPOSITORIES: EGA
Publications
Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients.
Nature communications 20150707
Pancreatic adenocarcinoma has the worst mortality of any solid cancer. In this study, to evaluate the clinical implications of genomic alterations in this tumour type, we perform whole-exome analyses of 24 tumours, targeted genomic analyses of 77 tumours, and use non-invasive approaches to examine tumour-specific mutations in the circulation of these patients. These analyses reveal somatic mutations in chromatin-regulating genes MLL, MLL2, MLL3 and ARID1A in 20% of patients that are associated w ...[more]
