Ontology highlight
ABSTRACT:
PROVIDER: EGAC00001000361 | EGA |
REPOSITORIES: EGA
Peifer Martin M Hertwig Falk F Roels Frederik F Dreidax Daniel D Gartlgruber Moritz M Menon Roopika R Krämer Andrea A Roncaioli Justin L JL Sand Frederik F Heuckmann Johannes M JM Ikram Fakhera F Schmidt Rene R Ackermann Sandra S Engesser Anne A Kahlert Yvonne Y Vogel Wenzel W Altmüller Janine J Nürnberg Peter P Thierry-Mieg Jean J Thierry-Mieg Danielle D Mariappan Aruljothi A Heynck Stefanie S Mariotti Erika E Henrich Kai-Oliver KO Gloeckner Christian C Bosco Graziella G Leuschner Ivo I Schweiger Michal R MR Savelyeva Larissa L Watkins Simon C SC Shao Chunxuan C Bell Emma E Höfer Thomas T Achter Viktor V Lang Ulrich U Theissen Jessica J Volland Ruth R Saadati Maral M Eggert Angelika A de Wilde Bram B Berthold Frank F Peng Zhiyu Z Zhao Chen C Shi Leming L Ortmann Monika M Büttner Reinhard R Perner Sven S Hero Barbara B Schramm Alexander A Schulte Johannes H JH Herrmann Carl C O'Sullivan Roderick J RJ Westermann Frank F Thomas Roman K RK Fischer Matthias M
Nature 20151014 7575
Neuroblastoma is a malignant paediatric tumour of the sympathetic nervous system. Roughly half of these tumours regress spontaneously or are cured by limited therapy. By contrast, high-risk neuroblastomas have an unfavourable clinical course despite intensive multimodal treatment, and their molecular basis has remained largely elusive. Here we have performed whole-genome sequencing of 56 neuroblastomas (high-risk, n = 39; low-risk, n = 17) and discovered recurrent genomic rearrangements affectin ...[more]