Dataset Information
MSKCC Medical Donation Program Data Access Committee
Ontology highlight
ABSTRACT:
PROVIDER: EGAC00001000588 | EGA |
REPOSITORIES: EGA
Publications
Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer.
Nature genetics 20170116 3
The extent of heterogeneity among driver gene mutations present in naturally occurring metastases-that is, treatment-naive metastatic disease-is largely unknown. To address this issue, we carried out 60× whole-genome sequencing of 26 metastases from four patients with pancreatic cancer. We found that identical mutations in known driver genes were present in every metastatic lesion for each patient studied. Passenger gene mutations, which do not have known or predicted functional consequences, ac ...[more]
