Genomics

Dataset Information

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NKI-AvL TGO DAC

ABSTRACT: Data Access Committee EGAC00001001051

PROVIDER: EGAC00001001051 | EGA |

REPOSITORIES: EGA

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Publications

Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression.

Carvalho B B   Postma C C   Mongera S S   Hopmans E E   Diskin S S   van de Wiel M A MA   van Criekinge W W   Thas O O   Matthäi A A   Cuesta M A MA   Terhaar Sive Droste J S JS   Craanen M M   Schröck E E   Ylstra B B   Meijer G A GA  

Gut 20081001 1

<h4>Objective</h4>This study aimed to identify the oncogenes at 20q involved in colorectal adenoma to carcinoma progression by measuring the effect of 20q gain on mRNA expression of genes in this amplicon.<h4>Methods</h4>Segmentation of DNA copy number changes on 20q was performed by array CGH (comparative genomic hybridisation) in 34 non-progressed colorectal adenomas, 41 progressed adenomas (ie, adenomas that present a focus of cancer) and 33 adenocarcinomas. Moreover, a robust analysis of alt  ...[more]

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