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Garvan Institute of Medical Research

ABSTRACT: Data Access Committee EGAC00001001300

PROVIDER: EGAC00001001300 | EGA |

REPOSITORIES: EGA

ACCESS DATA

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Publications

Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer.

Leong Tracy L TL Gayevskiy Velimir V Steinfort Daniel P DP De Massy Marc R MR Gonzalez-Rajal Alvaro A Marini Kieren D KD Stone Emily E Chin Venessa V Havryk Adrian A Plit Marshall M Irving Louis B LB Jennings Barton R BR McCloy Rachael A RA Jayasekara W Samantha N WSN Alamgeer Muhammad M Boolell Vishal V Field Andrew A Russell Prudence A PA Kumar Beena B Gough Daniel J DJ Gough Daniel J DJ Szczepny Anette A Ganju Vinod V Rossello Fernando J FJ Cain Jason E JE Papenfuss Anthony T AT Asselin-Labat Marie-Liesse ML Cowley Mark J MJ Watkins D Neil DN

Oncogene 20181022 10

Our understanding of genomic heterogeneity in lung cancer is largely based on the analysis of early-stage surgical specimens. Here we used endoscopic sampling of paired primary and intrathoracic metastatic tumors from 11 lung cancer patients to map genomic heterogeneity inoperable lung cancer with deep whole-genome sequencing. Intra-patient heterogeneity in driver or targetable mutations was predominantly in the form of copy number gain. Private mutation signatures, including patterns consistent ...[more]

PMID: 30348992

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