Dataset Information
BIH COVID-19 airway single-cell data access committee.
Ontology highlight
ABSTRACT:
PROVIDER: EGAC00001001627 | EGA |
REPOSITORIES: EGA
Publications
COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis.
Nature biotechnology 20200626 8
To investigate the immune response and mechanisms associated with severe coronavirus disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal and bronchial samples from 19 clinically well-characterized patients with moderate or critical disease and from five healthy controls. We identified airway epithelial cell types and states vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In patients with COVID-19, epithelial cells showed an ave ...[more]
