Dataset Information
CCRI COVID Patient Data Access Committee
Ontology highlight
ABSTRACT:
PROVIDER: EGAC00001001989 | EGA |
REPOSITORIES: EGA
Publications
SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8<sup>+</sup> T cell responses.
Science immunology 20210301 57
CD8<sup>+</sup> T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here, we identified nonsynonymous mutations in MHC-I-restricted CD8<sup>+</sup> T cell epitopes after deep sequencing of 747 SARS-CoV-2 virus isolates. Mutant peptides exhibited diminished or abrogated MHC-I binding in a cell-free in vitro assay. Reduced MHC-I binding of mutant peptides was associated with decreased proliferation, IFN-γ production and cytotoxic activity of CD8<sup>+</sup> T ...[more]