Project description:The Genetic Association Information Network (GAIN) Data Access Committee was established in June 2007 to provide prompt and fair access to data from six genome-wide association studies through the database of Genotypes and Phenotypes (dbGaP). Of 945 project requests received through 2011, 749 (79%) have been approved; median receipt-to-approval time decreased from 14 days in 2007 to 8 days in 2011. Over half (54%) of the proposed research uses were for GAIN-specific phenotypes; other uses were for method development (26%) and adding controls to other studies (17%). Eight data-management incidents, defined as compromises of any of the data-use conditions, occurred among nine approved users; most were procedural violations, and none violated participant confidentiality. Over 5 years of experience with GAIN data access has demonstrated substantial use of GAIN data by investigators from academic, nonprofit, and for-profit institutions with relatively few and contained policy violations. The availability of GAIN data has allowed for advances in both the understanding of the genetic underpinnings of mental-health disorders, diabetes, and psoriasis and the development and refinement of statistical methods for identifying genetic and environmental factors related to complex common diseases.

| S-EPMC3617375 | biostudies-literature

Data Access Committee

Project description:Data Access Committee EGAC00001002130

| EGAC00001002130 | EGA

Data Access Committee

Project description:Data Access Committee EGAC00001000657

| EGAC00001000657 | EGA

Data Access Committee

Project description:Data Access Committee EGAC00001002919

| EGAC00001002919 | EGA

Data Access Committee

Project description:Data Access Committee EGAC00001002967

| EGAC00001002967 | EGA

Data Access Committee

Project description:Data Access Committee EGAC00001000186

| EGAC00001000186 | EGA

Expression data from female SD rats with access to lifelong exercise

Project description:Gene expression and phenotypic consequences of laboratory housing in rats. Disease related-phenotypes and associated gene expressions of sedentary animals (living solely in a standard cage) were compared with animals that had access to twice-weekly one-hour physical activity in a large box (PA) and with those that had access to voluntary running wheel exercise (EX). Keywords: exercise dose reponse, sedentary, twice weekly physical activity, daily exercise

2006-07-01 | GSE5085 | GEO

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