Dataset Information
MRC Prion Unit Data Access Committee
Ontology highlight
ABSTRACT:
PROVIDER: EGAC01000000007 | EGA |
REPOSITORIES: EGA
Publications
Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP.
Human molecular genetics 20111230 8
Prion diseases are fatal neurodegenerative diseases of humans and animals caused by the misfolding and aggregation of prion protein (PrP). Mammalian prion diseases are under strong genetic control but few risk factors are known aside from the PrP gene locus (PRNP). No genome-wide association study (GWAS) has been done aside from a small sample of variant Creutzfeldt-Jakob disease (CJD). We conducted GWAS of sporadic CJD (sCJD), variant CJD (vCJD), iatrogenic CJD, inherited prion disease, kuru an ...[more]