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MolPAGE Data Access Committee

ABSTRACT: Data Access Committee EGAC01000000017

PROVIDER: EGAC01000000017 | EGA |

REPOSITORIES: EGA

ACCESS DATA

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Publications

Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes.

Min Josine L JL Nicholson George G Halgrimsdottir Ingileif I Almstrup Kristian K Petri Andreas A Barrett Amy A Travers Mary M Rayner Nigel W NW Mägi Reedik R Pettersson Fredrik H FH Broxholme John J Neville Matt J MJ Wills Quin F QF Cheeseman Jane J Allen Maxine M Holmes Chris C CC Spector Tim D TD Fleckner Jan J McCarthy Mark I MI Karpe Fredrik F Lindgren Cecilia M CM Zondervan Krina T KT

PLoS genetics 20120223 2

Metabolic Syndrome (MetS) is highly prevalent and has considerable public health impact, but its underlying genetic factors remain elusive. To identify gene networks involved in MetS, we conducted whole-genome expression and genotype profiling on abdominal (ABD) and gluteal (GLU) adipose tissue, and whole blood (WB), from 29 MetS cases and 44 controls. Co-expression network analysis for each tissue independently identified nine, six, and zero MetS-associated modules of coexpressed genes in ABD, ...[more]

PMID: 22383892

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