Dataset Information
RNA seq - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001000132 | EGA |
REPOSITORIES: EGA
Publications
The clonal and mutational evolution spectrum of primary triple-negative breast cancers.
Nature 20120404 7403
Primary triple-negative breast cancers (TNBCs), a tumour type defined by lack of oestrogen receptor, progesterone receptor and ERBB2 gene amplification, represent approximately 16% of all breast cancers. Here we show in 104 TNBC cases that at the time of diagnosis these cancers exhibit a wide and continuous spectrum of genomic evolution, with some having only a handful of coding somatic aberrations in a few pathways, whereas others contain hundreds of coding somatic mutations. High-throughput RN ...[more]
