Dataset Information
Ena-DATASET-Genentech-10-08-2012-19:36:55:498-15 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001000214 | EGA |
REPOSITORIES: EGA
Publications
Recurrent R-spondin fusions in colon cancer.
Nature 20120801 7413
Identifying and understanding changes in cancer genomes is essential for the development of targeted therapeutics. Here we analyse systematically more than 70 pairs of primary human colon tumours by applying next-generation sequencing to characterize their exomes, transcriptomes and copy-number alterations. We have identified 36,303 protein-altering somatic changes that include several new recurrent mutations in the Wnt pathway gene TCF7L2, chromatin-remodelling genes such as TET2 and TET3 and r ...[more]
