Dataset Information
Wgs_data_freeze_march_2013_DATA_SET_MMML_2012_11_06 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001000355 | EGA |
REPOSITORIES: EGA
Publications
Hypermutation of the inactive X chromosome is a frequent event in cancer.
Cell 20131017 3
Mutation is a fundamental process in tumorigenesis. However, the degree to which the rate of somatic mutation varies across the human genome and the mechanistic basis underlying this variation remain to be fully elucidated. Here, we performed a cross-cancer comparison of 402 whole genomes comprising a diverse set of childhood and adult tumors, including both solid and hematopoietic malignancies. Surprisingly, we found that the inactive X chromosome of many female cancer genomes accumulates on av ...[more]
