Ena-DATASET-GenCord2-27-05-2013-09:30:55:905-40 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001000428 | EGA |
REPOSITORIES: EGA
Publications
Passive and active DNA methylation and the interplay with genetic variation in gene regulation.
Gutierrez-Arcelus Maria M Lappalainen Tuuli T Montgomery Stephen B SB Buil Alfonso A Ongen Halit H Yurovsky Alisa A Bryois Julien J Giger Thomas T Romano Luciana L Planchon Alexandra A Falconnet Emilie E Bielser Deborah D Gagnebin Maryline M Padioleau Ismael I Borel Christelle C Letourneau Audrey A Makrythanasis Periklis P Guipponi Michel M Gehrig Corinne C Antonarakis Stylianos E SE Dermitzakis Emmanouil T ET
eLife 20130604
DNA methylation is an essential epigenetic mark whose role in gene regulation and its dependency on genomic sequence and environment are not fully understood. In this study we provide novel insights into the mechanistic relationships between genetic variation, DNA methylation and transcriptome sequencing data in three different cell-types of the GenCord human population cohort. We find that the association between DNA methylation and gene expression variation among individuals are likely due to ...[more]
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