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PCGP Histone-Capture bams - samples

ABSTRACT: DATA FILES FOR Histone Capture bams

PROVIDER: EGAD00001000657 | EGA |

REPOSITORIES: EGA

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Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia.

Jaffe Jacob D JD Wang Yan Y Chan Ho Man HM Zhang Jinghui J Huether Robert R Kryukov Gregory V GV Bhang Hyo-eun C HE Taylor Jordan E JE Hu Min M Englund Nathan P NP Yan Feng F Wang Zhaofu Z Robert McDonald E E Wei Lei L Ma Jing J Easton John J Yu Zhengtian Z deBeaumount Rosalie R Gibaja Veronica V Venkatesan Kavitha K Schlegel Robert R Sellers William R WR Keen Nicholas N Liu Jun J Caponigro Giordano G Barretina Jordi J Cooke Vesselina G VG Mullighan Charles C Carr Steven A SA Downing James R JR Garraway Levi A LA Stegmeier Frank F

Nature genetics 20130929 11

Epigenetic dysregulation is an emerging hallmark of cancers. We developed a high-information-content mass spectrometry approach to profile global histone modifications in human cancers. When applied to 115 lines from the Cancer Cell Line Encyclopedia, this approach identified distinct molecular chromatin signatures. One signature was characterized by increased histone 3 lysine 36 (H3K36) dimethylation, exhibited by several lines harboring translocations in NSD2, which encodes a methyltransferase ...[more]

PMID: 24076604

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