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Exome_seq_hepatcell_adenomas - samples

ABSTRACT: Whole exome sequencing data from 30 donors (46 tumors and 30 non-tumoral whole exome sequencing, paired-end, HiSeq 2000, Illumina) collected by the Inserm U674, PI Jessica Zucman-Rossi - Institut National du Cancer (INCa), PI Fabien Calvo, France.

PROVIDER: EGAD00001000737 | EGA |

REPOSITORIES: EGA

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Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets.

Schulze Kornelius K Imbeaud Sandrine S Letouzé Eric E Alexandrov Ludmil B LB Calderaro Julien J Rebouissou Sandra S Couchy Gabrielle G Meiller Clément C Shinde Jayendra J Soysouvanh Frederic F Calatayud Anna-Line AL Pinyol Roser R Pelletier Laura L Balabaud Charles C Laurent Alexis A Blanc Jean-Frederic JF Mazzaferro Vincenzo V Calvo Fabien F Villanueva Augusto A Nault Jean-Charles JC Bioulac-Sage Paulette P Stratton Michael R MR Llovet Josep M JM Zucman-Rossi Jessica J

Nature genetics 20150330 5

Genomic analyses promise to improve tumor characterization to optimize personalized treatment for patients with hepatocellular carcinoma (HCC). Exome sequencing analysis of 243 liver tumors identified mutational signatures associated with specific risk factors, mainly combined alcohol and tobacco consumption and exposure to aflatoxin B1. We identified 161 putative driver genes associated with 11 recurrently altered pathways. Associations of mutations defined 3 groups of genes related to risk fac ...[more]

PMID: 25822088

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