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J_Costello_20140127_dataset - samples

ABSTRACT: Dataset contains MeDIP-Seq, MRE-Seq and H3K4me3 ChIP-Seq data on 5 GBM patients.

PROVIDER: EGAD00001000777 | EGA |

REPOSITORIES: EGA

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Recurrent epimutations activate gene body promoters in primary glioblastoma.

Nagarajan Raman P RP Zhang Bo B Bell Robert J A RJ Johnson Brett E BE Olshen Adam B AB Sundaram Vasavi V Li Daofeng D Graham Ashley E AE Diaz Aaron A Fouse Shaun D SD Smirnov Ivan I Song Jun J Paris Pamela L PL Wang Ting T Costello Joseph F JF

Genome research 20140407 5

Aberrant DNA hypomethylation may play an important role in the growth rate of glioblastoma (GBM), but the functional impact on transcription remains poorly understood. We assayed the GBM methylome with MeDIP-seq and MRE-seq, adjusting for copy number differences, in a small set of non-glioma CpG island methylator phenotype (non-G-CIMP) primary tumors. Recurrent hypomethylated loci were enriched within a region of chromosome 5p15 that is specified as a cancer amplicon and also encompasses TERT, e ...[more]

PMID: 24709822

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