Dataset Information
PCGP Ph-likeALL WGS - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001000976 | EGA |
REPOSITORIES: EGA
Publications
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
The New England journal of medicine 20140901 11
<h4>Background</h4>Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. The frequency and spectrum of genetic alterations in Ph-like ALL and its responsiveness to tyrosine kinase inhibition are undefined, especially in adolescents and adults.<h4>Methods</h4>We performed genomic profiling of 1725 patients with precursor ...[more]