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Ena-DATASET-BCCA-13-08-2014-00:21:04:605-267 - samples

ABSTRACT: Multi-region whole genome sequencing of an high grade serous ovarian carcinoma sample for characterization of genomic intra-tumoural heterogeneity.

PROVIDER: EGAD00001000978 | EGA |

REPOSITORIES: EGA

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Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling.

Bashashati Ali A Ha Gavin G Tone Alicia A Ding Jiarui J Prentice Leah M LM Roth Andrew A Rosner Jamie J Shumansky Karey K Kalloger Steve S Senz Janine J Yang Winnie W McConechy Melissa M Melnyk Nataliya N Anglesio Michael M Luk Margaret T Y MT Tse Kane K Zeng Thomas T Moore Richard R Zhao Yongjun Y Marra Marco A MA Gilks Blake B Yip Stephen S Huntsman David G DG McAlpine Jessica N JN Shah Sohrab P SP

The Journal of pathology 20130901 1

High-grade serous ovarian cancer (HGSC) is characterized by poor outcome, often attributed to the emergence of treatment-resistant subclones. We sought to measure the degree of genomic diversity within primary, untreated HGSCs to examine the natural state of tumour evolution prior to therapy. We performed exome sequencing, copy number analysis, targeted amplicon deep sequencing and gene expression profiling on 31 spatially and temporally separated HGSC tumour specimens (six patients), including ...[more]

PMID: 23780408

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