Dataset Information
PCGP EWS WGS - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001001020 | EGA |
REPOSITORIES: EGA
Publications
Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations.
Cancer discovery 20140915 11
<h4>Unlabelled</h4>Ewing sarcoma is a primary bone tumor initiated by EWSR1-ETS gene fusions. To identify secondary genetic lesions that contribute to tumor progression, we performed whole-genome sequencing of 112 Ewing sarcoma samples and matched germline DNA. Overall, Ewing sarcoma tumors had relatively few single-nucleotide variants, indels, structural variants, and copy-number alterations. Apart from whole chromosome arm copy-number changes, the most common somatic mutations were detected in ...[more]
