Dataset Information
Ena-DATASET-GBM-18-12-2014-13:23:12:439-204 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001001112 | EGA |
REPOSITORIES: EGA
Publications
Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution.
Genome research 20150203 3
Glioblastoma (GBM) is a prototypical heterogeneous brain tumor refractory to conventional therapy. A small residual population of cells escapes surgery and chemoradiation, resulting in a typically fatal tumor recurrence ∼ 7 mo after diagnosis. Understanding the molecular architecture of this residual population is critical for the development of successful therapies. We used whole-genome sequencing and whole-exome sequencing of multiple sectors from primary and paired recurrent GBM tumors to rec ...[more]