Dataset Information
Ena-DATASET-MGH-10-02-2015-15:19:45:352-2 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001001253 | EGA |
REPOSITORIES: EGA
Publications
Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor.
Nature 20141117 7538
Broad and deep tumour genome sequencing has shed new light on tumour heterogeneity and provided important insights into the evolution of metastases arising from different clones. There is an additional layer of complexity, in that tumour evolution may be influenced by selective pressure provided by therapy, in a similar fashion to that occurring in infectious diseases. Here we studied tumour genomic evolution in a patient (index patient) with metastatic breast cancer bearing an activating PIK3CA ...[more]
